The Cancer Predisposition Program at the Aflac Cancer and Blood Disorders Center of Children's treats children under the age of 18 who are at risk for developing cancer due to a cancer predisposition syndrome, a family history of cancer or a diagnosis of a rare type of cancer.
What is a cancer predisposition syndrome?
A cancer predisposition syndrome is when an individual is born with a genetic mutation (or change) that increases his or her baseline risk for developing cancer. Estimates say that 10 percent of all pediatric cancers are caused by a cancer predisposition syndrome.
Pediatric cancer syndromes:
- Li-Fraumeni syndrome
- Leukemia and lymphoma predisposition syndromes
- Bloom syndrome
- DICER1 syndrome
- Familial adenomatous polyposis
- Von Hippel Lindau disease
- Constitutional mismatch repair deficiency syndrome
Types of tumors or malignancies that may suggest a pediatric cancer predisposition syndrome:
- Choroid plexus carcinoma
- Adrenocortical carcinoma
- Thyroid carcinoma (medullary)
- Pleuropulmonary blastoma
- Renal cell carcinoma
- Leukemia and lymphoma