The Pediatric Neurotrauma Lab, directed by Andrew Reisner, MD, is a multi-institutional collaboration between Children’s Healthcare of Atlanta and Emory University. Our mission is to establish a basic science research program focused on pediatric traumatic brain injury (TBI). We work to improve the health and quality of life of children living with acute neurological injuries, specifically TBI.
Through our large volume of pediatric neurotrauma patients, we use translational research to improve patient care. We collaborate with local and national researchers of all disciplines to advance the understanding and treatment of TBI.
The Pediatric Neurotrauma Lab’s mission is to facilitate research that can improve the treatment and outcomes of traumatic brain injuries in children.
Our lab focuses on three main areas of study:
Traumatic brain injury
A traumatic brain injury (TBI) occurs when an outside force is applied to the head and results in an interruption of normal brain function. The severity of a TBI can range from mild (a brief change in mental status or consciousness) to severe (an extended period of unconsciousness or amnesia).
TBI is a major public health problem and a leading cause of death and permanent disability in U.S. children and adolescents. The most common causes of TBI are sports injuries and motor vehicle accidents. The impact of TBI on a child and his or her family can be devastating.
A concussion is a mild form of TBI since they’re not usually life threatening and is caused by a bump, blow or jolt to the head. Concussions can also occur from a fall or a hit to the body that causes the head to move rapidly back and forth. Although most children make a complete recovery from a concussion, the effects of a concussion can occasionally be serious and long lasting. This is especially true if a child has second impact syndrome. This happens when a concussed brain is reinjured before it has recovered from its initial concussion. This is a serious and potentially fatal condition. We are collaborating to create guidelines that allow for careful, supervised return to play and return to school to help patients avoid this condition.
A biomarker, or biological marker, is something that can be easily measured to show the severity of a particular disease. Biomarkers can be used to guide treatments by measuring their response to a particular therapy. For example, doctors can test a patient’s blood glucose level in response to insulin.
Despite extensive research, there is no reliable biomarker for TBI to date. A critical part of our research at Children’s is locating a specific biomarker for TBI.
Children’s Neurotrauma Team Finds Evidence of COVID-19 Biomarker
After noting similarities between the inflammatory response observed in traumatic brain injury and COVID-19, Andrew Reisner, MD, led a pilot study showing evidence for a potential molecular indicator, or biomarker, for COVID-19 severity and multi-system inflammatory condition in children (MIS-C).Read more
According to the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS), translation is the process of turning observations in the lab, clinic and community into interventions that improve the health of individuals or populations.
The Pediatric Neurotrauma Lab at Children’s was set up to facilitate translational research on TBIs, including concussions. It is designed to complement our large clinical volume. The purpose of this research is to help find better treatments for pediatric TBI.
Translational research can encompass a spectrum of stages with the ultimate goal of moving understandings gained from basic research into interventions that improve the health of individuals and, ultimately, populations. NCATS recognizes that the full spectrum of translational research includes basic research (scientific exploration), preclinical research (applying fundamental discoveries), clinical research (clinical trials and health services research) and clinical implementation (adoption as routine practice and any resulting new questions or gaps in care).*
*National Center for Advancing Translational Sciences. “Translational Science Spectrum.” National Institutes of Medicine. Updated July 16, 2018. Retrieved Nov. 13, 2018, from https://ncats.nih.gov/translation.
Periodically, the Pediatric Neurotrauma Lab may have opportunities for others to get involved in its lab work and research.
If you are a student or researcher with an interest in translational research and a passion for improving outcomes for children and young people with TBI, we would love to hear from you.
Register your interest by emailing us at firstname.lastname@example.org.