Scientific Publications and Presentations

Publications

Cancer and Blood Disorders

Bello N.A., Hyacinth H.I., Roetker N.S., Seals S.R., Naik R.P., Derebail V.K., Kshirsagar A.V., Key N.S., Wilson J.G., Correa A., Adams R.J., Egede L.D., Longstreth W., Choudhary G., Gee B.E., Hughes A.L., Shah A.M., Manson J.E., Allison M., Burke G.L., Folsom A.R., Carty C.L., Reiner A.P., Solomon S.D., Konety S.H. “Sickle cell trait is not associated with an increased risk of heart failure or abnormalities of cardiac structure and function.” Blood. 2016. Epub 2016/12/10. DOI: 10.1182/blood-2016-08-705541. PMID: 27932373. 

Cash T., McIlvaine E., Krailo M.D., et al. "Comparison of Clinical Features and Outcomes in Patients with Extraskeletal Versus Skeletal Localized Ewing Sarcoma: A Report from the Children's Oncology Group" Pediatric Blood Cancer, June 14, 2016. DOI: 10.1002/pbc.26096. PMID: 27297500

Dong L., Yu W.M., Zheng H., Loh M.L., Bunting S.T., Pauly M., Huang G., Zhou M., Broxmeyer H.E., Scadden D.T., and Qu C.K. “Leukemogenic effects of Ptpn11 (Shp2) activating mutations in the stem cell microenvironment”  Nature, 2016.  In press.

Liu W., Yu W.M., Zhang J., Chan R.J., Loh M.L., Zhang Z., and Qu C.K. “Inhibition of the Gab2/PI3K/mTOR Signaling Ameliorates the Myeloid Malignancy Caused by Ptpn11 (Shp2) Gain-of-Function Mutations” Leukemia, 2016. In press.

Myers, D.R, Qiu Y., Fay M.E., Tennenbaum M., Chester D., Cuadrado J., Sakurai Y., Baek J., Tran R., Ciciliano J., Ahn B., Mannino R., Bunting S., Bennett C., Briones M., Fernandez-Nieves A., Smith M.L., Brown A.C., Sulchek T., Lam W.A. “Single-platelet nanomechanics measured by high-throughput cytometry” Nature Materials. In press.

Pitter K.L., Tamagno I., Alikhanyan K., Hosni-Ahmed A., Pattwell S.S., Donnola S., Dai C., Ozawa T., Chang M., Chan T.A., Beal K., Bishop A.J., Barker C.A., Jones T.S., Hentschel B., Gorlia T., Schlegel U., Stupp R., Weller M., Holland E.C., Hambardzumyan D. “Corticosteroids compromise survival in glioblastoma” Brain, 139(Pt 5):1458-71, May 2016. doi: 10.1093/brain/aww046. PMID:  27020328

Deng W., Xu Y., Chen W., Paul D.S., Syed A.K., Dragovich M.A., Liang X., Zakas P., Berndt M.C., Di Paola J., Ware J., Lanza F., Doering C.B., Bergmeier W., Zhang X.F., Li R. “Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor” Nature Communications 27;7:12863, Sept. 2016. doi: 10.1038/ncomms12863. PMID: 27670775

Zakas P.M., Brown H.C., Knight K., Meeks S.L., Spencer H.T., Gaucher E.A., and Doering C.B. “Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction” Nature Biotechnology, Sept. 26, 2016. doi: 10.1038/nbt.3677. [Epub ahead of print]  PMID: 27669166

Cardiology

Phelps HM, Kelleman MS, McCracken CE, Benavidez OJ, Campbell RM, Douglas PS, Eidem BW, Lai WW, Lopez L, Stern KW, Welch E, Sachdeva R. Application of Pediatric Appropriate Use for Initial Outpatient Evaluation of Syncope. Echocardiography. 2017 Mar;34(3):441-445. doi: 10.1111/echo.13475. Epub 2017 Feb 8.

Hoeting NM, McCracken CE, McConnell M, Sallee D, Iannucci GJ, Oster ME. Systolic ejection click versus split first heart sound: Are our ears deceiving us? Congenit Heart Dis. 2017 Mar 16 [Epub ahead of print]

Hashemi S, Parks WJ, Sallee D 3rd, Slesnick T. Double Aortic Arch With Previously Undescribed Head and Neck Vessel Branching. Can J Cardiol. 2017 Apr;33(4):555.e21-555.e23.

Tree M, Trusty PM, Slesnick TC, Yoganathan A, Deshpande S, Maher K. In Vitro Examination of the HeartWare CircuLite Ventricular Assist Device in the Fontan Connection. ASAIO J. 2017 Jan 20. doi: 10.1097/MAT.0000000000000521. [Epub ahead of print]

Rose-Felker K, Border WL, Hong BJ, Chow EJ. Cardio-oncology Related to Heart Failure: Pediatric Considerations for Cardiac Dysfunction. Heart Fail Clin. 2017 Apr;13(2):311-325. doi: 10.1016/j.hfc.2016.12.007. Review. PubMed PMID: 28279417.

Grant EK, Kim DW, Border WL, Lerakis S, Babaliaros V, Vincent RN. Transseptal Anchored Vascular Plug Closure of Mitral Valve Perforation. JACC Cardiovasc Interv. 2017 Mar 13;10(5):e45-e46. doi: 10.1016/j.jcin.2016.12.004. Epub 2017 Feb 15. PubMed PMID: 28216218.

McLaughlin ES, Travers C, Border WL, Deshpande S, Sachdeva R. Tricuspid annular plane systolic excursion as a marker of right ventricular dysfunction in pediatric patients with dilated cardiomyopathy. Echocardiography. 2017 Jan;34(1):102-107. doi: 10.1111/echo.13416. Epub 2016 Dec 9. PubMed PMID: 27933640

Alsoufi B, McCracken C, Shashidharan S, Kogon B, Border W, Kanter K. Palliation Outcomes of Neonates Born With Single-Ventricle Anomalies Associated With Aortic Arch Obstruction. Ann Thorac Surg. 2017 Feb;103(2):637-644. doi: 10.1016/j.athoracsur.2016.06.040. Epub 2016 Sep 1. PubMed PMID: 27592600.

Naguib M, Kanaan U, Simon D, Guglani L. Risk factors for development of PH in infants with BPD: systemic review and meta-analysis. Paediatric Respiratory Reviews (epub ahead of print)

Hebson C, Book W, Elder R, Ford R, Jokhadar M, Kanter K, Kogon B, Kovacs AH, Levit RD, Lloyd M, Maher K, Reshamwala P, Rodriguez F, Romero R, TejadaT, Marie, Valente A, Veldtman G, McConnell M.. Frontiers in Fontan failure: A summary of conference proceedings. Congenit Heart Dis 12:6-16, 2017.

Jacobs JP, LaheySJ, Nichols FC, Levett JM, Johnston GG, Cleveland JC, DiSesa VJ, Freeman RK, St. Louis JD, Painter J, Yohe C, Wright CD, Kanter KR, Mayer JE, Naunheim KS, Rich JB, Bavaria JE: How is physician work valued? Ann Thorac Surg 103:373-80, 2017.

Nathan M, Jacobs ML, Gaynor JW, Newburger JW, Masterson CD, Lambert LM, Hollenbeck-Pringle D, Trachtenberg FL, White O, Anderson BR, Bell MC, Burch PT, Graham EM, Kaltman JR, Kanter KR, Mery CM, Pizarro C, Schamberger MS, Taylor MD, Jacobs JP, Pasquali SK: Completeness and accuracy of local clinical registry data for children undergoing heart surgery.  Ann Thorac Surg 103:629-36, 2017.

Baldwin JT, Adachi I, Teal J, Almond CA, Jaquiss RD, Massicotte MP, Dasse K, Siami FS, Zak V, Kaltman JR, Mahle WT, Jarvik R. Closing in on the PumpKIN Trial of the Jarvik 2015 Ventricular Assist Device.  Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2017 Jan;20:9-15.

Karsch E, Irving SY, Aylward BS, Mahle WT. The prevalence and effects of aspiration among neonates at the time of discharge. Cardiol Young. 2017 Feb 6:1-7. doi: 10.1017/S104795111600278X. [Epub ahead of print]

Sacks JH, Flueckiger PB, Spandorfer PR, Mahle WT, Costello BE. Adult Chest Pain in the Pediatric Emergency Department: Treatment and Timeliness From Door In To Door Out. Pediatr Emerg Care. 2017 Mar 21. doi: 10.1097/PEC.0000000000001081 [Epub ahead of print]

Rose-Felker K, Kelleman MS, Campbell RM, Sachdeva R. Appropriateness of Outpatient Echocardiograms Ordered by Pediatric Cardiologists or Other Clinicians. J Pediatr. 2017 Feb 24. pii: S0022-3476(17)30183-X. doi: 10.1016/j.jpeds.2017.01.073. [Epub ahead of print]

Concussion

Keith H. May, P.T., D.P.T., S.C.S., A.T.C., C.S.C.S., David L. Marshall, M.D., Thomas G. Burns, Psy.D., ABPP/CN, David M. Popoli, M.D., John A. Polikandriotis, Ph.D., MBA, MPH, FACHE. Pediatric sports specific return to play guidelines following concussion. International Journal of Sports Physical Therapy, 9(2), pp. 242-255.

David Popoli, M.D., Thomas G. Burns, Psy.D., ABPP/CN, Meehan WP 3rd, Andrew Reisner, M.D. CHOA concussion consensus: establishing a uniform policy for academic accommodations. Clinical Pediatrics. 2014 Mar;53(3):217-24. doi: 10.1177/0009922813499070. Epub 2013 Aug 19.
Read more

Andrew Reisner, M.D., F.A.C.S., F.A.A.P.; Natalie Tillman, R.N., B.S.N.; Linda Cole, R.N.; Elizabeth Atkins, R.N.; Greg Pereira, R.N., B.S.N., M.B.A., Mary Thacher, R.N., MSN, CEN. Concussion in Children. Neuro Update Vol 5, Issue 1, 2011. Dr. Reisner and the Children’s concussion team take a look at the history of concussions and provide insight into the definitions, guidelines and treatments for a condition that affects millions of children each year.

Burns, T.G. & Yosick, R. (2012). Book Review: Kirkwood, M.W., & Yeates, K.O. (2012). Mild Traumatic Brain Injury in Children and Adolescents: From Basic Science to Clinical Management. New York, NY. The Guilford Press. Applied Neuropsychology: Child, 2(1), pp.78-79.

Arenivas, A. & Burns, T.G. (2012). Recent Trends in Pediatric and Adolescent Concussion: How to Diagnose and Treat This Condition. Book Review: Apps, J.N. & Walter, K.D. (Eds). (2012). Pediatric and Adolescent Concussion: Diagnosis, Management, and Outcomes. New York: Springer. The Clinical Neuropsychologist, 1-3.

American Academy of Pediatrics. Point of Care Quick Reference: Head Injuries. Pediatric Care Online.

Atabaki SM. Pediatric head injury. Pediatrics in Review. 2007 Jun; 28(6): 215-24.
Bin, SS, Schutzman SA and Greenes DS. Validation of a clinical score to predict skull fracture in head injured infants. Ped Emer Care 26 (9) Sept 2010: 633-639.

Brody AS, Frush DP and Brent RL. Radiation risk to children from computed tomography. PED 120(3) Sept 2007; 677-682.

Centers for Disease Control and Prevention. Heads up: concussion in youth sports.

Hall Eric J. Lessons we have learned from our children: cancer risks from diagnostic radiology.
Pediatr Rad (2002)32:700-706.

Kluger J. (2011, January 31). Headbanger nation. Time, 177, 42-51.

Kupperman N et al. Identification of children at very low risk of clinically important brain injuries after head trauma: a prospective cohort. Lancet 2009: 374:1160-70.

Palchak MJ et al. A decision rule for identifying children at low risk for brain injuries after blunt head trauma. Ann Emer Med Oct 2003: 42:4; 492-506.

Palchak MJ et al. Does an isolated history of low of consciousness or amnesia predict brain injuries in children after blunt head trauma? PED 113:6; June 2004; e507-513.

Pauline Anderson. (2010, September 10). New guidance on management of increasing problem of sports-related concussions in children. Medscape Medical News.

Practice guidelines: the management of minor closed head injury in children. PED 1998; 104; 6:1407-1415.

Schnadower D et al. Controversies in the evaluation and management of minor blunt head trauma in children. Curr Opin Ped 2007;19:258-264.

Schutzman SA et al. Evaluation and management of children younger than two years old with apparently minor head trauma: proposed guidelines. PED 107(5) May 2001 983-993.

Neurology

Language and social functioning in children and adolescents with epilepsy. Byars AW, DeGrauw TJ, Johnson CS, Perkins SM, Fastenau PS, Dunn DW, Austin JK. Epilepsy Behav. 2014 Feb;31:167-71. doi: 10.1016/j.yebeh.2013.11.007. Epub 2014 Jan 14

Neuropsychology

Howarth, R.A., Reisner, A., Chern, J., Hayes, L., Burns, T.G., & Berenstein, A. (2015). Neurocognitive improvements following endovascular repair for Vein of Galen arteriovenous malformation in childhood: A case report. Journal of Neurosurgery: Pediatrics, 15, 197-202.

Burns, T.G. & Loring, D.W (2015). Psychological and social impact of epilepsy: pediatric and adolescent review. Journal of Pediatric Epilepsy, 4(3), pp. 1-7.

Reisner, A., Popoli, D.M., Burns, T.G., Marshall, D.L., Jain, S., Hall, L., Vova, J.A., Kroll, S., Wesselman, B.C., Palasis, S., Hayes, L., Clark, G., Speake, K.M., Holbrook, B.H., Wiskind, R.H., Licata, R.M., Ono, K.E., Hogan, E., Chern, J., DeGrauw, T. (2015). The Central Role of Community Practicing Pediatricians in Contemporary Concussion Care: A Case Study of CHOA’s Concussion Program. Clinical Pediatrics, pp. 1-7

Bodin, D., Roper, B., O’Toole, K., & Haines, M.E. (2015). Postdoctoral training in clinical neuropsychology: A review of the history, trends, and current issues. Training and Education in Professional Psychology.

McManus, S. & O’Toole, K. (2014). Book Review: Language Disorders in Children and Adolescents, by Joseph H. Beitchman & Elizabeth B. Brownlie. Child Neuropsychology. Published online: 23 May, 1-3.

Howarth, R.A., Adamson, A.M., Ashford, J.M., Merchant, T.E., Ogg, R.J., Schulenberg, S.E., Ogg, S., Li, J., Wu, S., Xiong, X, & Conklin, H.M. (2014). Investigating the relationship between COMT polymorphisms and working memory performance among childhood brain tumor survivors. Pediatric Blood & Cancer, 61, 40-45.

Jackson, S., Patay, Z., Howarth, R.A., Panandiker, A.S., Onar-Thomas, A., Gajjar, A., & Broniscer, A. (2013). Clinico-radiologic characteristics and neurocognitive assessment of long-term survivors of diffuse intrinsic pontine glioma. Journal of Neuro-Oncology, 114, 339-344.

Howarth, R.A., Ashford, J.M., Merchant, T.E., Ogg, R.J., Santana, V., Wu, S., Xiong, X., & Conklin, H.M. (2013). The utility of parent report in the assessment of working memory among childhood brain tumor survivors. Journal of the International Neuropsychological Society, 19, 380-389.

Alriksson-Schmidt, A.I., Thibadeau, J.K., Swanson, M.E., Marcus, D., Carris, K.L., Siffel, C., Ward, E., (2013). The Natural History of Spina Bifida in Children Pilot Project: A Research Protocol. JMIR Research Protocols (2013)

Sun, B., Berl, M.M., Burns, T.G., Gaillard, W.D., Hayes, L., Adjouadi, M., & Jones, R.A (2013). Age Association of Language Task Induced Deactivation Induced in a Pediatric Population. Neuroimage, 65, 232-33.

Burns, T.G., King, T.Z., & Spencer, K.S. (2012). Mullen Scales of Early Learning: The Utility in Assessing Children with Autism Spectrum Disorders, Cerebral Palsy, and Epilepsy. Journal of Applied Neuropsychology: Child, 1, pp. 1-10.

Sun, B., Brown, R.C., Hayes, L., Burns, T.G., Huamani, J., Bearden, D.J., & Jones, R.A. (2012). White matter damage in asymptomatic patients with sickle cell anemia: Screening with diffusion tensor imaging. American Journal of Neuroradiology, 33, pp. 1-7.

Burns, T.G. (2012). Book Review: Sherman, E.M.S., & Brooks, B.L. (Eds). (2012). Pediatric forensic Neuropsychology. New York, NY: Oxford University Press. Applied Neuropsychology: Child, (In press)

Christopher, G. & O’Toole, K. (2012). Book Review: Barkley, Russell. Executive Functions. New York: Guilford Press. “The chasm cries out for a bridge.” Child Neuropsychology, iFirst, 1-4.

Micklewright, J.L., King, T.Z., O’Toole, K., Henrich, C., & Floyd, F.J. (2012). Authoritarian Parenting Partially Mediates the Relationship between Parental Stress and Child Adaptive Outcomes 12-36 Months Following Traumatic Brain Injury. Journal of the International Neuropsychological Society, 18, 1-8.

Conklin, H.C., Ashford, J.A., Howarth, R.A., Merchant, T.E., Ogg, R.J., Santana, V., et al. (2012). Working memory performance among childhood brain tumor survivors. Journal of the International Neuropsychological Society, 18, 996-1005.

Neurosurgery

Read selected journal articles authored/co-authored by our surgeons available at PubMed, the online database provided by the U.S. National Library of Medicine National Institutes of Health publications:

View more on PubMed

Return to system within 30 days of discharge following pediatric shunt surgery. Joshua J. Chern, M.D., Ph.D., Markus Bookland, M.D., Javier Tejedor-Sojo, M.D., Jonathan Riley, M.D., Mohamm adali M. Shoja, M.D., R. Shane Tubb s, Ph.D., P.A.-C., and Andrew Reisner, M.D. J Neurosurg: Pediatrics / March 14, 2014 DOI: 10.3171/2014.2.PEDS13493

Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres. Anjana Jain, Martha Betancur, Gaurangkumar D. Patel, Chandra M. Valmikinathan, Vivek J. Mukhatyar, Ajit Vakharia, S. Balakrishna Pai, Barunashish
Brahma, Tobey J. MacDonald & Ravi V. Bellamkonda. Nature Materials 13, 308–316 (2014) doi:10.1038/nmat3878. Published online 16 February 2014

Aguilera, Flamini, Boydston, et al; Response of subependymal giant cell astrocytoma with spinal cord mestasis to everolimus. Journal of Pediatric Hematology/Oncology

Reisner A, Gary MF, Chern JJ, D Grattan-Smith: Spinal cord infarction following minor trauma in children; Fibrocartilaginous embolism as a putative cause: J Neurosurgery: Pediatrics, April Vol 11, 445-450, 2013.

Kebriaei MA, Shoa MM, Salinas SM, Falkenstrom KL, Sibnick, EA, Tubbs RS, Reisner A,Chern JJ; Shunt infection in the first year of life. Journal of Neurosurgery: Pediatrics July 12:44-48, 2013.

David M. Popoli, MD, Thomas Burns, PhD, William Meehan III, MD, Andrew Reisner, MD. CHOA Concussion Consensus: Establishing a Uniform Policy for Academic Accomodations. J Pediatrics (accepted)

A Heads up on Craniosynostosis, Andrew Reisner, M.D., William R. Boydston, M.D., Ph.D., Barun Brahma, M.D.; Joshua Chern, M.D., Ph.D., David Wrubel, M.D.

Abnormalities of Headshape in an Infant, Andrew Reisner, M.D., William R. Boydston, M.D., Ph.D., Barun Brahma, M.D.; Joshua Chern, M.D., Ph.D., David Wrubel, M.D.

Neuro Spine Care for Kids, David Wrubel, M.D., and Barun Brahma, M.D.

The "Epidemic" of Occipital Flattening: Why It Is Happening and What To Do About It, Andrew Reisner, M.D., William R. Boydston, M.D., Ph.D., Barun Brahma, M.D.; Joshua Chern, M.D., Ph.D., David Wrubel, M.D.

Pediatric Radiosurgery and Gamma Knife, Andrew Reisner, M.D., F.A.C.S., F.A.A.P.

Low Grade Leptomeningeal Neuroepithelial Tumor, Schniederjan, et al

Evans Blue Nanocarriers Visuall Demarcate Margins of Invasive Gliomas, Roller, et al

Nanofiber Transport of Brain Tumors, Jain et al

The Use of Inside-Outside Screws for Occipitocervial Fusion in Pediatric Patients – Accepted for publication in the Journal of Neurosurgery: Pediatrics

Transient enlargement of craniopharyngioma after radiation therapy; Pattern of MRI response following radiation. Journal of Neurooncology September 2012; 109(2); 349-55

Maurice SM, Brahma B, Burnstein FD. Disappearing dermoid: Fact or Fiction? Journal of Craniofacial Surgery. May 2012; 23(3): 812-6

Nanoparticle Liposome-Imipramine Blue inhibits medulloblastoma in SmoA1 transgenic mice.

Chern JJ, Kirkman JL, Shannon CN, Tubbs RS, Stone JD, Royal SA, Oakes WJ, Rozzelle CJ, Wellons JC. Use of lumbar ultrasonography to detect occult spinal dysraphism. Journal Neurosurgery Pediatric. 9(3):274-9, 2012.

Tubbs RS, Hattab EM, Loukas M, Chern JJ, Wellons M, Wellons JC 3rd, Iskandar BJ, Cohen-Gadol AA. Histological analysis of the third ventricle floor in hydrocephalic and non hydrocephalic brains: application to neuroendocrine complications following third ventriculostomy procedures. Journal Neurosurgery Pediatrics. 9(2):178-181, 2012.

Chern JJ, Tubbs RS, Gordon AS, Donnithorne KJ, Oakes WJ. Management of Pediatric Patients with Pseudotumor Cerebri. Childs Nerv Syst. 28(4):575-578, 2012 Jan 19.

Chern JJ, Muhleman M, Tubbs RS, Miller JH, Johnston JM, Wellons JC 3rd, Blount JP, Oakes WJ, Rozzelle CJ. Clinical evaluation and surveillance imaging in children with Spina Bifida aperta and shunt-treated hydrocephalus. J Neurosurgery Pediatrics. 9(6): 621-6, 2012.

Hwang SW, Gressot LV, Chern JJ, Relyea K, Jea A. Complications of Occipital Screw Placement for Occipitolcervical Fusion in Childres. J Neurosurgery Pediatrics. 9(6); 586-93, 2012.

Tubbs RS, Chern JJ, Muhleman M, Loukas M, Shoja MM, Oakes WJ. Lateral Compressions of the Foramen Magnum with the Chiari 1 Malformation: case illustrations. Childs Nerv Syst Apr 19, 2012.

Tubbs RS, Muhleman M, McClugage SG, Loukas M, Miller JH, Chern JJ, Rozzelle CJ, Oakes WJ, Cohen-Gadol AA. Progressive symptomative increase in the size of choroidal fissure cysts. J Neurosurg Pediatr 10(4):306-9, 2012.

Chern JJ, Aksut B, Kirkman JL, Shoja MM, Tubbs RS, Royal SA, Wellons JC 3rd, Rozzelle CJ. The accuracy of abnormal lumbar sonography findings in detecting occult spinal dysraphism: a comparison with magnetic resonance imaging. J Neurosurg Pediatr. 10(2): 150-3, 2012.

Kebriaei MA, Shoa MM, Salinas SM, Falkenstrom KL, Sibnick, EA, Tubbs RS, Reisner a. Chern JJ; Shunt infection in the first year of life. Journal of Neurosurgery: Pediatrics July 12:44-48, 2013.

Chern JJ. Response, Spinal dysraphism. J Neurosurg Pediatr. 11(5): 613, 2013.

Tubbs RS, Mortazavi MM, Farrington WJ, Chern JJ, Shoja MM, Loukas M, Cohen-Gadol AA. Relationships between the posterior interosseous nerve and the supinator muscle: application to peripheral nerve compression syndromes and nerve transfer procedures. J Neurol Surg A Cent Eur Neurosurg, 2013 May 21.

Reisner A, Gary MF, Chern JJ, D Grattan-Smith: Spinal cord infarction following minor trauma in children; Fibrocartilaginous embolism as a putative cause: J Neurosurgery: Pediatrics, April Vol 11, 445-450, 2013.

Rizk E, Chern JJ, tagayun C, Tubbs RS, Hankinson T, Rozzelle CJ, Oakes WJ, Blount JP, Wellons JC. Institutional experience of endoscopic suprasellar arachnoid cyst fenestration. Childs Nerv Syst Jan 24, 2013.

Shoja MM, Chern JJ. Letter to the editor: Decompressive craniectomy. J Neurosurg Pediatr 11(3): 358, 2013.

Orthopaedics

Micheli anterior cruciate ligament reconstruction in skeletally immature youths: A retrospective case series with a mean 3-year follow up

PI: S. Clifton Willimon, M.D., Michael Busch M.D.
This study is to evaluate the clinical outcomes of a physeal-sparing technique using the illotibial band for combined intra-articular and extra-articular ACL reconstruction. At a mean 3-year follow-up, the study findings confirmed excellent functional outcomes, a low ACL revision rate, and no growth disturbances.

Willimon SC, Jones CR, Herzog MM, May KH, Leake MJ, Busch MT. Micheli anterior cruciate ligament reconstruction in skeletally immature youths: A retrospective case series with a mean 3-year follow-up. Am J Sports Med. 2015 [Epub ahead of print] PMID: 26498959

Subscapularis avulsion of the lesser tuberosity in adolescent

PI: Michael Busch M.D.
This study is a long-term clinical follow-up study of patients with isolated lesser tuberosity avulsions in skeletally immature patients. Operative treatment consisted of a diagnostic arthroscopy to evaluate for concomitant pathology, followed by an open reattachment of the tuberosity through an incision in line with the anterior axillary fold.

Garrigues GE, Warnick DE, Busch MT. Subscapularis avulsion of the lesser tuberosity in adolescent. J Pediatr Orthop. 2013;33(1):8-13. [PMID 23232372]

Effects of bracing in adolescents with idiopathic scoliosis (BrAIST)

PI: Michael Schmitz, M.D., National Institutes of Health
The BrAIST study is a Phase III, multicenter, prospective partially-randomized, partially blinded clinical trial, designed to determine whether the use of the thoracolumbosacral orthoses (brace) lowers the risk of curve progression in patients with adolescent idiopathic scoliosis (AIS) relative to observation (watchful waiting).

Weinstein SL, Dolan LA, Wright JG, Dobbs MB. Effects of bracing in adolescents with idiopathic scoliosis. N Engl J Med. 2013;369(16):1512-1521. [PMID: 23232372]

Grants

Cancer and Blood Disorders

Cheng-Kui Qu, M.D., Ph.D. received the Hyundai Hope on Wheels Scholar Award (PI), September 2016 to August 2018, “Targeting Shp2 phosphatase for chemoprevention of leukemic progression in Noonan Syndrome”, Direct cost: $125,000 per year

Cheng-Kui Qu, M.D., Ph.D. received NIH R01 award (PI), August 2016 to June 2020, “Germline mutations of PTPN11(SHP-2) in the stem cell microenvironment”, Director cost: $250,000 per year

Christopher Doering, Ph.D. and H. Trent Spencer, Ph.D. received NIH/NHLBI R56 award (PIs), September 2016 to August 2017, “Ancestral Sequence Reconstruction Engineering of Coagulation Factors” $255,000

Christopher Doering, Ph.D. and H. Trent Spencer, Ph.D. received NIH/NHLBI R43 award (MPI: Doering/Spencer/Denning) September 2016 to August 2017, “Lead Candidate Liver-Directed AAV-FVIII Expression Cassette” $225,000

H. Trent Spencer, Ph.D. and Christopher Doering, Ph.D. received a Hemophilia of Georgia, Inc. Research Grant (Spencer PI, Doering Co-PI), October 2016 to September 2018,  “Hematopoietic Stem Cell Gene Therapy for Hemophilia A” $437,574 per year (twice a year)

Hyacinth Hyacinth, M.D., Ph.D., MPH, Instructor of Pediatrics at Emory University, received a $225,000 grant from the NIH that will run from July 2017 through June 2022. Dr. Hyacinth is the principal investigator on the grant, which will study the mechanism of cerebral vasculopathy in sickle cell disease.

Elizabeth Stenger, M.D., Assistant Professor of Pediatrics at Emory University, received a $187,812 K23 grant from the NIH that will run from August 2016 to July 2020 for her work on improving haplo-identical stem cell transplantation in sickle cell disease using autologous mesenchymal stromal cells (MSCs).