Scientific Publications and Presentations


Cancer and Blood Disorders


Q1 Publications: January-March 2019

Smith CA, McCracken C, Thomas A, Spector L, St. Louis JD, Oster ME, Moller J, Kochilas L. Long-term Outcomes of Tetralogy of Fallot: A Study from the Pediatric Cardiac Care Consortium. JAMA Cardiology. 2019 Jan 1;4(1):34-41.

Wright L, Knight JH, Thomas AS, Oster ME, St. Louis J, Kochilas L. Long-Term Outcomes After Intervention for Pulmonary Atresia with Intact Ventricular Septum: A Study from the Pediatric Cardiac Care Consortium. Heart. 2019;105:1007-1013.

Zaki NC, Kelleman MS, Parks JW, Slesnick TC, McConnell ME, Oster ME. The utility of cardiac magnetic resonance imaging in post-Fontan surveillance. Congenit Heart Dis, 2019;14(2):140-6.

Frommelt PC, Slesnick TC, Newburger JW. Impact of initial shunt type on echocardiographic indices in children after single right ventricle palliations. Circ Cardiovasc Imaging, 2019;12(2).

Alsoufi B, Rosenblum J, Travers C, Kanter K, Trusty PM, Yoganathan AP, Slesnick T. Outcomes of single ventricle patients undergoing the Kawashima procedure: Can we do better? World J Pediatr Congenit Heart Surg, 2019;10(1):20-27.

Graham EM, Martin RH, Atz AM, Hamlin-Smith K, Kavarana MN, Bradley SM, Alsoufi B, Mahle WT, Everett AD. Association of intraoperative circulating-brain injury biomarker and neurodevelopmental outcomes at 1 year among neonates who have undergone cardiac surgery. J Thorac Cardiovasc Surg. 2019 Jan 23. pii: S0022-5223(19)30250-8. doi: 10.1016/j.jtcvs.2019.01.040. [Epub ahead of print]

C. Ibezim and A.L. Sarvestani, J.H. Knight, O. Qayum, N. Alshami, E. Turk, J. St. Louis, C. McCracken, J.H. Moller, L. Kochilas, G. Raghuveer: “Outcomes of Mechanical Mitral Valve Replacement in Children Annals of Thoracic Surgery 2019;107:143-150 (DOI: 10.1016/ j.athoracsur.2018.07.069).

Beshish AG, Bradley JD, McDonough KL, Halligan NLN, McHugh WM, Sturza J, Hall MW, Cornell TT, Dahmer MK. The Functional Immune Response of Patients on Extracorporeal Life Support. ASAIO J. 2019 Jan;65(1):77-83.

Gaies M, Ghanayem NS, Alten JA, Costello JM, Lasa JJ, Chanani NK, Shin AY, Retzloff L, Zhang W, Pasquali SK, Banerjee M, Tabbutt S. Variation in Adjusted Mortality for Medical Admissions to Pediatric Cardiac ICUs. Pediatr Crit Care Med. 2019 Feb;20(2):143-148.

Ho SS, Patel MM, Mansour RM, Vats A, Chanani NK, Rostad BS. Portable CT Pulmonary Angiogram in an Infant on Veno-Arterial Extracorporeal Membrane Oxygenation in the Pediatric Intensive Care Unit. Curr Probl Diagn Radiol. 2019 Mar - Apr;48(2):189-192.

Boucek DM, Qureshi AM, Goldstein BH, Petit CJ, Glatz AC. Blalock-Taussig shunt versus patent ductus arteriosus stent as first palliation for ductal-dependent pulmonary circulation lesions: A review of the literature. Congenit Heart Dis. 2019 Jan;14(1):105-109.

Aggarwal V, Petit CJ, Glatz AC, Goldstein BH, Qureshi AM. Stenting of the ductus arteriosus for ductal-dependent pulmonary blood flow-current techniques and procedural considerations. Congenit Heart Dis. 2019 Jan;14(1):110-115.

Quinn BP, Armstrong AK, Bauser-Heaton HD, Callahan R, El-Said HG, Foerster SR, Goldstein BH, Goodman AS, Gudausky TM, Kreutzer JN, Leahy RA, Petit CJ, Rockefeller TA, Shahanavaz S, Trucco SM, Bergersen L; Congenital Cardiac Catheterization Project on Outcomes-Quality Improvement (C3PO-QI). Radiation Risk Categories in Cardiac Catheterization for Congenital Heart Disease: A Tool to Aid in the Evaluation of Radiation Outcomes. Pediatr Cardiol. 2019 Feb;40(2):445-453.

Martin GR, Anderson JB, Vincent RN. IMPACT Registry and National Pediatric Cardiology Quality Improvement Collaborative: Contributions to Quality in Congenital Heart Disease. World J Pediatr Congenit Heart Surg. 2019 Jan;10(1):72-80.

Q2 Publications: April-June 2019

Kogon BE, Oster ME, Wallace A, Chiswell K, Hill KD, Cox ML, Jacobs JP, Pasquali S, Karamlou T, Jacobs ML. Readmission After Pediatric Cardiothoracic Surgery: An Analysis of the Society of Thoracic Surgeons Database. Annals of Thoracic Surgery. 2019 Jun;107(6):1816-1823.

Jenkins KJ, Botto LD, Correa A, Foster E, Kupiec J, Marino B, Oster ME, Stout KK, Honein MA. A Public Health Approach to Improve Outcomes for Congenital Heart Disease across the Lifespan. J Am Heart Assoc. 2019;8:e009450

Lupo PJ, Schraw JM, Desrosiers TA, Nembhard WN, Langlois PH, Canfield MA, Copeland G, Meyer RE, Brown AL, Chambers TM, Sok P, Danysh HE, Carozza SE, Sisoudiya SD, Hilsenbeck SG, Janitz AE, Oster ME, Scheuerle AE, Schiffman JD, LuoC, MIan A, Mueller BA, Huff CD, Rasmussen SA, Scheurer M, Plon SE. Cancer Risk among Children and Adolescents with Birth Defects: A Population-Based Assessment in 10 Million Live Births. JAMA Oncology. [Epub ahead of print]

Downing K, Colarusso T, Gilboa S, Lin A, Oster ME, Tinker S, Farr S, and the National Birth Defects Prevention Study. Potential Risk Factors for Ebstein Anomaly, National Birth Defects Prevention Study, 1997-2011. Cardiology in the Young. [Epub ahead of print]

Smith CA Jr, Oster ME, Kochilas L. We Can Learn From the Past, but We Must Pave the Future of Congenital Heart Disease Research-Reply. JAMA Cardiology. [Epub ahead of print]

Prospero C, Trachtenberg F, Pasquali S, Anderson B, Ash K, Bainton J, Dunbar-Masterson C, Graham E, Hamstra M, Hollenbeck-Pringle D, Jacobs J, Jacobs M, John R, Lambert L, Oster M, Swan E, Waldron A, Nathan M. Lessons Learned in the Use of Clinical Registry Data in a Multicenter Prospective Study: The Pediatric Heart Network Residual Lesion Score Study. Cardiology in the Young. [Epub ahead of print]

Oster ME, McCracken C, Kiener A, Aylward B, Cory M, Hunting J, Kochilas L. Long-Term Survival of Patients with Coarctation Repaired During Infancy (From the Pediatric Cardiac Care Consortium). American Journal of Cardiology. (In press)

Pasquali SK, Kaltman JR, Gaynor JW, McCrindle BW, Newburger JW, Anderson BR, Schuerer MA, Pinto NM, Anderson JB, Oster ME, Jacobs JP, Marino BS, Mery C, Pearson GD. Enhancing Efficiency and Scientific Impact of a Clinical Trials Network: The Pediatric Heart Network Integrated CARdiac Data and Outcomes (iCARD) Collaborative. Cardiology in the Young. (In press)

Dasgupta S, Kelleman M, Slesnick T, Oster ME. Cardiomegaly on Chest Radiographs as a Predictor of Heart Disease in the Pediatric Population. Am J Emergency Medicine. (Epub)

McHugh KE, Mahle WT, Hall MA, Scheurer MA, Moga MA, Triedman J, Nicolson SC, Amula V, Cooper DS, Schamberger M, Wolf M, Shekerdemian L, Burns KM, Ash KE, Hipp DM, Pasquali SK. Hospital Costs Related to Early Extaubtion after Infant Cardiac Surgery. May 2019. Ann Thorac Surg 107(5): 1421-1426

Gaies M, Pasquali SK, Nicolson SC, Shekerdemian L, Witte M, Wolf M, Zhang W, Donohue JE, Mahle WT. Sustainability of Infant Cardiac Surgery Early Extubation Practices after Implementation and Study. May 2019. Ann Thorac Surg 107(5): 1427-1433

Bates K, Wolf M, Retzloff L, Donohue J, Gaies M, Nicolson S, Shekerdemian L, Witte M, Shea J, Likosky D, Mahle W, Pasquali S. Variation in implementation and outcomes across sites participating in the Pediatric Heart Network (PHN) Early Extubation Collaborative Learning. May 2019. Ann Thorac Surg 107(5): 1434-1440

Miller, TA, Ghanayem NS, Newburger JW, McCrindle BW, Hu C, DeWitt AG, Cnota JF, Tractenberg FL, Pemberton VL, Wolf MJ, Votava-Smith JK, Fifer CG, Lambert LM, Shah A, Graham EM, Pizarro C, Jacobs JP, Miller SG, Minich LL. Gestational Age, Birth Weight, and Outcomes Six Years after the Norwood Procedure. May 2019. Pediatrics 143(5): e20182577

Dasgupta S, Fischbach P, Kanaan U. Prolonged Sinus Pause Following Ingestion of a Button Battery. Progress in Pediatric Cardiology, Accepted, in Press

Kanaan U, : Varghese NP, Coleman RD , Huckaby J, Lawrence P, Jorgensen LO, Miller-Reed K, Day RW, Mallory GB, Ivy DD. Oral treprostinil use in children: a multi-center, observational experience. Pulmonary Circulation, Accepted, in press.

Bauser-Heaton H, Ma M, Wise-Faberowski L, Asija R, Shek J, Zhang Y, Peng LF, Sidell DR, Hanley FL, McElhinney DB. Outcomes After Initial Unifocalization to a Shunt in Complex Tetralogy of Fallot with MAPCAs. Ann Thorac Surg. Jun; 107 (6): 1807-1815.

Holly Bauser-Heaton, MD, PhD, Michael Ma, MD, Doff B. McElhinney, MD, Yulin Zhang, PhD, Frandics P. Chan, MD, Ritu Asija, MD, Jennifer Shek, NP, Lisa Wise-Faberowski, MD, Frank L. Hanley, MD, Mid-Term Outcomes After Surgical Aortopulmonary Window in Patients with Tetralogy of Fallot with Hypoplastic Central Pulmonary Arteries and Dual-Supply Collaterals. Ann Thorac Surg 2019 April 10

Lisa Wise-Faberowski, Matthew Irvin, Michael Lennig, Jin Long, Helen R. Nadel, Holly Bauser-Heaton, Ritu Asija, Frank L. Hanley, Doff B. McElhinney. Assessment of the Reconstructed Pulmonary Circulation with Lung Perfusion Scintigraphy After Unifocalization and Repair of Tetralogy of Fallow With Major Aortopulmonary Collaterals. World Journal for Pediatric and Congenital Heart Surgery. 2019 May; 10 (3): 313-320.

Yinn Khurn Ooi, Robert N. Vincent, Michael Kelleman, R. Allen Ligon, Holly D. Bauser-Heaton, Dennis W. Kim, Christopher J. Petit. Thomboprophylaxis Strategies for Children with Single Ventricle Circulations (Superior or Total Cavo-Pulmonary Connections) after Stent Placement. Cardiology in the Young. June 2019. Epub ahead of print 

Zoghbi WA, Slesnick TC, Zimmerman KG. Guidelines for the evaluation of valvular regurgitation after percutaneous valve repair or replacement: A report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Angiography and Interventions, Japanese Society of Echocardiography, and Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr, 2019;32(4):431-75.

Saung MT, McCracken C, Sachdeva R, Petit CJ. Outcomes Following Balloon Aortic Valvuloplasty Versus Surgical Valvotomy in Congenital Aortic Valve Stenosis: A Meta-Analysis. J Invasive Cardiol. 2019 Jun;31(6):E133-E142.

Dasgupta S, Friedman H, Allen N, Stark M, Ferguson E, Sachdeva R, Border WL. Exercise stress echocardiography: Impact on clinical decision-making in pediatric patients. Echocardiography. 2019 May;36(5):938-943. doi: 10.1111/echo.14326. Epub 2019 Apr 1.

Dasgupta S, Dave I, McCracken CE, Mohl L, Sachdeva R, Border W. Burnout and work-life balance among pediatric cardiologists: A single center experience. Congenit Heart Dis. 2019 May;14(3):350-355. doi: 10.1111/chd.12723. Epub 2018 Dec 2

McHugh KE, Mahle WT, Hall MA, Scheurer MA, Moga MA, Triedman J, Nicolson SC, Amula V, Cooper DS, Schamberger M, Wolf M, Shekerdemian L, Burns KM, Ash KE, Hipp DM, Pasquali SK; Pediatric Heart Network Investigators. Hospital Costs Related to Early Extubation after Infant Cardiac Surgery. Ann Thorac Surg. 2019 May;107(5):1421-1426

Bates KE, Mahle WT, Bush L, Donohue J, Gaies MG, Nicolson SC, Shekerdemian L, Witte M, Wolf M, Shea JA, Likosky DS, Pasquali SK. Variation in Implementation and Outcomes of Early Extubation Practices After Infant Cardiac Surgery. Ann Thorac Surg. 2019 May;107(5):1434-1440

Mahle WT. Commentary: Window of brain protection after congenital heart surgery-Is it still open? J Thorac Cardiovasc Surg. 2019 Apr 4. pii: S0022-5223(19)30748-2. doi: 10.1016/j.jtcvs.2019.03.070. [Epub ahead of print]

Chubb H, Campbell RM, Motonaga KS, Ceresnak SR, Dubin AM.  Management of Asymptomatic Wolff-Parkinson-White Pattern by Pediatric Electrophysiologists. The Journal of Pediatrics.  Accepted for publication, May 2019

Knight LM, Miller E, Kovach J, Arscott P, von Alvensleben JC, Bradley D, Valdes SO, Ware SM, Meyers L, Travers CD, Campbell RM, Etheridge SP, Genetic Testing and Cascade Screening in Pediatric Long QT Syndrome and Hypertrophic Cardiomyopathy, Heart Rhythm (2019), doi:

Goldstein SA, Beshish AG, Bush LB, Lowery RE, Wong JH, Schumacher KR, Halligan NLN, Cornell TT, Rocchini AP. Analysis of Inflammatory Cytokines in Postoperative Fontan Pleural Drainage. Pediatr Cardiol. 2019 Apr;40(4):744-752.

Chen Y, Chow EJ, Oeffinger KC, Border WL, Leisenring WM, Meacham LR, Mulrooney DA, Sklar CA, Stovall M, Robison LL, Armstrong GT, Yasui Y. Traditional cardiovascular risk factors and individual prediction of cardiovascular events in childhood cancer survivors. J Natl Cancer Inst. 2019 Jun 4. pii: djz108. doi: 10.1093/jnci/djz108. [Epub ahead of print]

Petit CJ, Qureshi AM, Glatz AC, McCracken CE, Kelleman M, Nicholson GT, Meadows JJ, Shahanavaz S, Zampi JD, Law MA, Pettus JA, Goldstein BH. Comprehensive comparative outcomes in children with congenital heart disease: The rationale for the Congenital Catheterization Research Collaborative. Congenit Heart Dis. 2019 May;14(3):341-349.

Saung MT, McCracken C, Sachdeva R, Petit CJ. Outcomes Following Balloon Aortic Valvuloplasty Versus Surgical Valvotomy in Congenital Aortic Valve Stenosis: A Meta-Analysis. J Invasive Cardiol. 2019 Jun;31(6):E133-E142.

Goldstein BH, O'Byrne ML, Petit CJ, Qureshi AM, Dai D, Griffis HM, France A, Kelleman MS, McCracken CE, Mascio CE, Shashidharan S, Ligon RA, Whiteside W, Wallen WJ, Agrawal H, Aggarwal V, Glatz AC. Differences in Cost of Care by Palliation Strategy for Infants With Ductal-Dependent Pulmonary Blood Flow. Circ Cardiovasc Interv. 2019 Apr;12(4):e007232.

Qureshi AM, Goldstein BH, Glatz AC, Agrawal H, Aggarwal V, Ligon RA, McCracken C, McDonnell A, Buckey TM, Whiteside W, Metcalf CM, Petit CJ. Classification scheme for ductal morphology in cyanotic patients with ductal dependent pulmonary blood flow and association with outcomes of patent ductus arteriosus stenting. Catheter Cardiovasc Interv. 2019 Apr 1;93(5):933-943.

Allen Ligon R, Petit CJ. Working backward: Retrograde balloon angioplasty of atretic arteries in chronic thromboembolic pulmonary hypertension. Catheter Cardiovasc Interv. 2019 May 1;93(6):1076-1079.



Recent Publications 

Murdaugh, D., Ono, K.E., Morris S., Burns, T.G. (2018). Effects of Developmental Age on Symptom Reporting and Neurocognitive Performance in Youth After Sports-Related Concussion Compared to Control Athletes.

Murdaugh, D., Ono, K.E., Reisner, A., Burns, T.G. (2018). Assessment of Sleep Quantity and Sleep Disturbances During Recovery from Sports-Related Concussion in Young Athletes. Archives of Physical Medicine and Rehabilitation.

Reisner, A, Burns, T.G., Hall, L.B., Jain, S., Weselman, B.C., De Grauw, T.J., Ono, K.E., Blackwell, L., Chern, J.J. (2017). Quality Improvement in Concussion Care: Influence of Guideline-Based Education, The Journal of Pediatrics, 2017 May;184:26-31. doi: 10.1016/j.jpeds.2017.01.045. Epub 2017 Feb 21. PMID: 28233546

Keith H. May, P.T., D.P.T., S.C.S., A.T.C., C.S.C.S., David L. Marshall, M.D., Thomas G. Burns, Psy.D., ABPP/CN, David M. Popoli, M.D., John A. Polikandriotis, Ph.D., MBA, MPH, FACHE. Pediatric sports specific return to play guidelines following concussion. International Journal of Sports Physical Therapy, 9(2), pp. 242-255.

David Popoli, M.D., Thomas G. Burns, Psy.D., ABPP/CN, Meehan WP 3rd, Andrew Reisner, M.D. CHOA concussion consensus: establishing a uniform policy for academic accommodations. Clinical Pediatrics. 2014 Mar;53(3):217-24. doi: 10.1177/0009922813499070. Epub 2013 Aug 19.

Andrew Reisner, M.D., F.A.C.S., F.A.A.P.; Natalie Tillman, R.N., B.S.N.; Linda Cole, R.N.; Elizabeth Atkins, R.N.; Greg Pereira, R.N., B.S.N., M.B.A., Mary Thacher, R.N., MSN, CEN. Concussion in Children. Neuro Update Vol 5, Issue 1, 2011. Dr. Reisner and the Children’s concussion team take a look at the history of concussions and provide insight into the definitions, guidelines and treatments for a condition that affects millions of children each year.

Download all concussion publications and presentations


Language and social functioning in children and adolescents with epilepsy. Byars AW, DeGrauw TJ, Johnson CS, Perkins SM, Fastenau PS, Dunn DW, Austin JK. Epilepsy Behav. 2014 Feb;31:167-71. doi: 10.1016/j.yebeh.2013.11.007. Epub 2014 Jan 14


Howarth, R.A., Reisner, A., Chern, J., Hayes, L., Burns, T.G., & Berenstein, A. (2015). Neurocognitive improvements following endovascular repair for Vein of Galen arteriovenous malformation in childhood: A case report. Journal of Neurosurgery: Pediatrics, 15, 197-202.

Burns, T.G. & Loring, D.W (2015). Psychological and social impact of epilepsy: pediatric and adolescent review. Journal of Pediatric Epilepsy, 4(3), pp. 1-7.

Reisner, A., Popoli, D.M., Burns, T.G., Marshall, D.L., Jain, S., Hall, L., Vova, J.A., Kroll, S., Wesselman, B.C., Palasis, S., Hayes, L., Clark, G., Speake, K.M., Holbrook, B.H., Wiskind, R.H., Licata, R.M., Ono, K.E., Hogan, E., Chern, J., DeGrauw, T. (2015). The Central Role of Community Practicing Pediatricians in Contemporary Concussion Care: A Case Study of CHOA’s Concussion Program. Clinical Pediatrics, pp. 1-7

Bodin, D., Roper, B., O’Toole, K., & Haines, M.E. (2015). Postdoctoral training in clinical neuropsychology: A review of the history, trends, and current issues. Training and Education in Professional Psychology.

McManus, S. & O’Toole, K. (2014). Book Review: Language Disorders in Children and Adolescents, by Joseph H. Beitchman & Elizabeth B. Brownlie. Child Neuropsychology. Published online: 23 May, 1-3.

Howarth, R.A., Adamson, A.M., Ashford, J.M., Merchant, T.E., Ogg, R.J., Schulenberg, S.E., Ogg, S., Li, J., Wu, S., Xiong, X, & Conklin, H.M. (2014). Investigating the relationship between COMT polymorphisms and working memory performance among childhood brain tumor survivors. Pediatric Blood & Cancer, 61, 40-45.

Jackson, S., Patay, Z., Howarth, R.A., Panandiker, A.S., Onar-Thomas, A., Gajjar, A., & Broniscer, A. (2013). Clinico-radiologic characteristics and neurocognitive assessment of long-term survivors of diffuse intrinsic pontine glioma. Journal of Neuro-Oncology, 114, 339-344.

Howarth, R.A., Ashford, J.M., Merchant, T.E., Ogg, R.J., Santana, V., Wu, S., Xiong, X., & Conklin, H.M. (2013). The utility of parent report in the assessment of working memory among childhood brain tumor survivors. Journal of the International Neuropsychological Society, 19, 380-389.

Alriksson-Schmidt, A.I., Thibadeau, J.K., Swanson, M.E., Marcus, D., Carris, K.L., Siffel, C., Ward, E., (2013). The Natural History of Spina Bifida in Children Pilot Project: A Research Protocol. JMIR Research Protocols (2013)

Sun, B., Berl, M.M., Burns, T.G., Gaillard, W.D., Hayes, L., Adjouadi, M., & Jones, R.A (2013). Age Association of Language Task Induced Deactivation Induced in a Pediatric Population. Neuroimage, 65, 232-33.

Burns, T.G., King, T.Z., & Spencer, K.S. (2012). Mullen Scales of Early Learning: The Utility in Assessing Children with Autism Spectrum Disorders, Cerebral Palsy, and Epilepsy. Journal of Applied Neuropsychology: Child, 1, pp. 1-10.

Sun, B., Brown, R.C., Hayes, L., Burns, T.G., Huamani, J., Bearden, D.J., & Jones, R.A. (2012). White matter damage in asymptomatic patients with sickle cell anemia: Screening with diffusion tensor imaging. American Journal of Neuroradiology, 33, pp. 1-7.

Burns, T.G. (2012). Book Review: Sherman, E.M.S., & Brooks, B.L. (Eds). (2012). Pediatric forensic Neuropsychology. New York, NY: Oxford University Press. Applied Neuropsychology: Child, (In press)

Christopher, G. & O’Toole, K. (2012). Book Review: Barkley, Russell. Executive Functions. New York: Guilford Press. “The chasm cries out for a bridge.” Child Neuropsychology, iFirst, 1-4.

Micklewright, J.L., King, T.Z., O’Toole, K., Henrich, C., & Floyd, F.J. (2012). Authoritarian Parenting Partially Mediates the Relationship between Parental Stress and Child Adaptive Outcomes 12-36 Months Following Traumatic Brain Injury. Journal of the International Neuropsychological Society, 18, 1-8.

Conklin, H.C., Ashford, J.A., Howarth, R.A., Merchant, T.E., Ogg, R.J., Santana, V., et al. (2012). Working memory performance among childhood brain tumor survivors. Journal of the International Neuropsychological Society, 18, 996-1005.


Read selected journal articles authored/co-authored by our surgeons available at PubMed, the online database provided by the U.S. National Library of Medicine National Institutes of Health publications:

View more on PubMed

Return to system within 30 days of discharge following pediatric shunt surgery. Joshua J. Chern, M.D., Ph.D., Markus Bookland, M.D., Javier Tejedor-Sojo, M.D., Jonathan Riley, M.D., Mohamm adali M. Shoja, M.D., R. Shane Tubb s, Ph.D., P.A.-C., and Andrew Reisner, M.D. J Neurosurg: Pediatrics / March 14, 2014 DOI: 10.3171/2014.2.PEDS13493

Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres. Anjana Jain, Martha Betancur, Gaurangkumar D. Patel, Chandra M. Valmikinathan, Vivek J. Mukhatyar, Ajit Vakharia, S. Balakrishna Pai, Barunashish
Brahma, Tobey J. MacDonald & Ravi V. Bellamkonda. Nature Materials 13, 308–316 (2014) doi:10.1038/nmat3878. Published online 16 February 2014

Aguilera, Flamini, Boydston, et al; Response of subependymal giant cell astrocytoma with spinal cord mestasis to everolimus. Journal of Pediatric Hematology/Oncology

Reisner A, Gary MF, Chern JJ, D Grattan-Smith: Spinal cord infarction following minor trauma in children; Fibrocartilaginous embolism as a putative cause: J Neurosurgery: Pediatrics, April Vol 11, 445-450, 2013.

Kebriaei MA, Shoa MM, Salinas SM, Falkenstrom KL, Sibnick, EA, Tubbs RS, Reisner A,Chern JJ; Shunt infection in the first year of life. Journal of Neurosurgery: Pediatrics July 12:44-48, 2013.

David M. Popoli, MD, Thomas Burns, PhD, William Meehan III, MD, Andrew Reisner, MD. CHOA Concussion Consensus: Establishing a Uniform Policy for Academic Accomodations. J Pediatrics (accepted)

A Heads up on Craniosynostosis, Andrew Reisner, M.D., William R. Boydston, M.D., Ph.D., Barun Brahma, M.D.; Joshua Chern, M.D., Ph.D., David Wrubel, M.D.

Abnormalities of Headshape in an Infant, Andrew Reisner, M.D., William R. Boydston, M.D., Ph.D., Barun Brahma, M.D.; Joshua Chern, M.D., Ph.D., David Wrubel, M.D.

Neuro Spine Care for Kids, David Wrubel, M.D., and Barun Brahma, M.D.

The "Epidemic" of Occipital Flattening: Why It Is Happening and What To Do About It, Andrew Reisner, M.D., William R. Boydston, M.D., Ph.D., Barun Brahma, M.D.; Joshua Chern, M.D., Ph.D., David Wrubel, M.D.

Pediatric Radiosurgery and Gamma Knife, Andrew Reisner, M.D., F.A.C.S., F.A.A.P.

Low Grade Leptomeningeal Neuroepithelial Tumor, Schniederjan, et al

Evans Blue Nanocarriers Visuall Demarcate Margins of Invasive Gliomas, Roller, et al

Nanofiber Transport of Brain Tumors, Jain et al

The Use of Inside-Outside Screws for Occipitocervial Fusion in Pediatric Patients – Accepted for publication in the Journal of Neurosurgery: Pediatrics

Transient enlargement of craniopharyngioma after radiation therapy; Pattern of MRI response following radiation. Journal of Neurooncology September 2012; 109(2); 349-55

Maurice SM, Brahma B, Burnstein FD. Disappearing dermoid: Fact or Fiction? Journal of Craniofacial Surgery. May 2012; 23(3): 812-6

Nanoparticle Liposome-Imipramine Blue inhibits medulloblastoma in SmoA1 transgenic mice.

Chern JJ, Kirkman JL, Shannon CN, Tubbs RS, Stone JD, Royal SA, Oakes WJ, Rozzelle CJ, Wellons JC. Use of lumbar ultrasonography to detect occult spinal dysraphism. Journal Neurosurgery Pediatric. 9(3):274-9, 2012.

Tubbs RS, Hattab EM, Loukas M, Chern JJ, Wellons M, Wellons JC 3rd, Iskandar BJ, Cohen-Gadol AA. Histological analysis of the third ventricle floor in hydrocephalic and non hydrocephalic brains: application to neuroendocrine complications following third ventriculostomy procedures. Journal Neurosurgery Pediatrics. 9(2):178-181, 2012.

Chern JJ, Tubbs RS, Gordon AS, Donnithorne KJ, Oakes WJ. Management of Pediatric Patients with Pseudotumor Cerebri. Childs Nerv Syst. 28(4):575-578, 2012 Jan 19.

Chern JJ, Muhleman M, Tubbs RS, Miller JH, Johnston JM, Wellons JC 3rd, Blount JP, Oakes WJ, Rozzelle CJ. Clinical evaluation and surveillance imaging in children with Spina Bifida aperta and shunt-treated hydrocephalus. J Neurosurgery Pediatrics. 9(6): 621-6, 2012.

Hwang SW, Gressot LV, Chern JJ, Relyea K, Jea A. Complications of Occipital Screw Placement for Occipitolcervical Fusion in Childres. J Neurosurgery Pediatrics. 9(6); 586-93, 2012.

Tubbs RS, Chern JJ, Muhleman M, Loukas M, Shoja MM, Oakes WJ. Lateral Compressions of the Foramen Magnum with the Chiari 1 Malformation: case illustrations. Childs Nerv Syst Apr 19, 2012.

Tubbs RS, Muhleman M, McClugage SG, Loukas M, Miller JH, Chern JJ, Rozzelle CJ, Oakes WJ, Cohen-Gadol AA. Progressive symptomative increase in the size of choroidal fissure cysts. J Neurosurg Pediatr 10(4):306-9, 2012.

Chern JJ, Aksut B, Kirkman JL, Shoja MM, Tubbs RS, Royal SA, Wellons JC 3rd, Rozzelle CJ. The accuracy of abnormal lumbar sonography findings in detecting occult spinal dysraphism: a comparison with magnetic resonance imaging. J Neurosurg Pediatr. 10(2): 150-3, 2012.

Kebriaei MA, Shoa MM, Salinas SM, Falkenstrom KL, Sibnick, EA, Tubbs RS, Reisner a. Chern JJ; Shunt infection in the first year of life. Journal of Neurosurgery: Pediatrics July 12:44-48, 2013.

Chern JJ. Response, Spinal dysraphism. J Neurosurg Pediatr. 11(5): 613, 2013.

Tubbs RS, Mortazavi MM, Farrington WJ, Chern JJ, Shoja MM, Loukas M, Cohen-Gadol AA. Relationships between the posterior interosseous nerve and the supinator muscle: application to peripheral nerve compression syndromes and nerve transfer procedures. J Neurol Surg A Cent Eur Neurosurg, 2013 May 21.

Reisner A, Gary MF, Chern JJ, D Grattan-Smith: Spinal cord infarction following minor trauma in children; Fibrocartilaginous embolism as a putative cause: J Neurosurgery: Pediatrics, April Vol 11, 445-450, 2013.

Rizk E, Chern JJ, tagayun C, Tubbs RS, Hankinson T, Rozzelle CJ, Oakes WJ, Blount JP, Wellons JC. Institutional experience of endoscopic suprasellar arachnoid cyst fenestration. Childs Nerv Syst Jan 24, 2013.

Shoja MM, Chern JJ. Letter to the editor: Decompressive craniectomy. J Neurosurg Pediatr 11(3): 358, 2013.


Learn about our current pediatric orthopaedic research efforts

Past publications 2013-2016


Neumann JA, Mannava S, Busch MT, et al. Arthroscopic debridement of pediatric accessory anterolateral talar facet causing impingement.
Arthrosc Tech 2016;5(3):413-417.

Sugimoto D, Christino MA, Micheli LJ. Effects of surgical intervention on trochlear remodeling in pediatric patients with recurrent patella dislocation cases.
J Pediatr Orthop B 2016;25(4):349-353.

Christino MA, Fleming BC, Machan JT, et al. Psychological factors associated with anterior cruciate ligament reconstruction recovery.
Orthop J Sports Med 2016;4(3).

Sugimoto D, Christino MA, Micheli LJ. Effects of surgical intervention on trochlear remodeling in pediatric patients with recurrent patellar dislocation cases.
J Pediatr Orthop B 2016;25(4):349-353.

Reaume J, Reaume D, Christino MA. Psychological aspects of ACL rehabilitation. Lower Extremity Review Magazine 2016.

Heyworth BE, Christino MA. Anterior cruciate ligament tears in skeletally immature athletes. Orthopaedic Knowledge Update Sports Medicine, ed 5. Rosemont, IL: American Academy of Orthopaedic Surgeons. 2016.

Christino MA, Mansuripur PK, Hayda R. Trauma. Comprehensive board review in orthopedic surgery. New York, NY: Thieme. 2016.

Schmitz, ML. and Giavedoni, BJ. Congenital longitudinal deficiencies of the fibula. AAOS Atlas of Amputations and Limb Deficiencies- Surgical, Prosthetic, and Rehabilitation Principles, 4th Ed 2016;Chapter 73:865-872

Schrader T, Jones CR, Kaufman AM, et al. Intraoperative monitoring of epiphyseal perfusion in slipped capital femoral epiphysis. J Bone Joint Surg Am 2016;98(12):1030-1040.

Willimon SC, Gaskill TR, Millett PJ. Acromioclavicular joint injuries: anatomy, diagnosis, and treatment. Phys Sports Med 2016;39(1):116 – 122.

Herzog MM, Axelrod JR, Willimon SC, et al. Functional outcomes following nonoperative versus operative treatment of clavicle fractures in adolescents. Pediatrics 2016;137(3).

Siegall E, Willimon SC, Busch MT, et al. Age predicts disruption of the articular surface of the femoral condyles in knee OCD: Can we reduce usage of the arthroscopy and MRI? J Pediat Ortho 2016.


Truntzer J, Vopat ML, Christino MA, et al. Forearm diaphyseal fractures in the adolescent population: treatment and management. Eur J Orthop Surg Traumatol 2015;25(2):201-209.

Christino MA, Vopat BG, Mayer A, et al. Stability outcomes following computer-assisted ACL reconstruction. Minimally Invasive Surgery 2015.

Vopat BG, Daniels AH, Christino MA, et al. Hybrid anterolateral approach for open reduction internal fixation of femoral neck fractures.
Orthopedics 2015;38(7):430-434.

Christino MA, Fantry A, Vopat BG. Psychological aspects of recovery following anterior cruciate ligament reconstruction. J Am Acad Orthop Surg 2015;23(8):501-509. 

Murphy JS, Mubarak SJ. Talocalcaneal coalitions. Foot Ankle Clin. 2015;20(4):681-91.

Wilcox, WR, Coulder, CP, Schmitz, ML. Congenital limb deficiencies. Clinics in Perinatology 42:281-300, 2015

Schrader T, Ward WT. Pericapsular osteotomies of pemberton and dega. In Wiesel S (Ed), Operative Techniques in Orthopaedic Surgery: 1924-1933. 2015.

Hyman JE, Trupia, Schrader T, et al. Interobserver and intraobserver reliability of the modified Waldenstrom classification system for staging of Legg-Calve-Perthes disease.
J Bone Joint Surg 2015;97(8):643-650.

Willimon SC, Jones CR, Herzog MM, May KH, Leake MJ, Busch MT. Micheli anterior cruciate ligament reconstruction in skeletally immature youths: A retrospective case series with a mean 3-year follow-up. Am J Sports Med 2015;43(12): 2974-2981.

  • This study is to evaluate the clinical outcomes of a physeal-sparing technique using the illotibial band for combined intra-articular and extra-articular ACL reconstruction. At a mean 3-year follow-up, the study findings confirmed excellent functional outcomes, a low ACL revision rate, and no growth disturbances.

McLaren K, Byrd E, Willimon, SC, et al. Impact shoulder angles correlate with impact wrist angles in standing back handsprings in preadolescent and adolescent female gymnasts.
International journal of sports physical therapy 2015;10(3).

Steadman JR, Briggs KK, Willimon SC, et al. Outcomes following microfracture of full-thickness articular cartilage lesions of the knee in adolescent patients.
Journal of Knee Surgery 2015;28(2):145-150.


Archibald-Seiffer N, Weiss J, Busch MT. Cases and current concepts in pediatric sports medicineJ Pediatr Orthop 2014;34:S49-S56.

Christino MA, Vopat BG, Waryasz GR, et al. Adolescent differences in knee stability following computer-assisted ACL reconstruction.
Orthopedic Reviews 2014;6(4).

Vopat ML, Kane PM, Christino MA, et al. Treatment of forearm fractures in children.
Orthopedic Reviews 2014;6(2).

Fletcher ND, Shourbaji N, Devito DP, et al. Clinical and economic implications of early discharge following posterior spinal fusion for adolescent idiopathic scoliosis.
J Child Orthop 2014;8(3):257-263.

Willimon SC, Briggs, KK, Philippon MJ. Intra-articular adhesions following hip arthroscopy: a risk factor analysis. Knee Surgery, Sports Traumatology Arthroscopy 2014;22(4):822-825.


Garrigues GE, Warnick DE, Busch MT. Subscapularis avulsion of the lesser tuberosity in adolescent. J Pediatr Orthop. 2013;33(1):8-13. [PMID 23232372]

  • This study is a long-term clinical follow-up study of patients with isolated lesser tuberosity avulsions in skeletally immature patients. Operative treatment consisted of a diagnostic arthroscopy to evaluate for concomitant pathology, followed by an open reattachment of the tuberosity through an incision in line with the anterior axillary fold.

PI: Michael Schmitz, M.D., National Institutes of Health

The BrAIST study is a Phase III, multicenter, prospective partially-randomized, partially blinded clinical trial, designed to determine whether the use of the thoracolumbosacral orthoses (brace) lowers the risk of curve progression in patients with adolescent idiopathic scoliosis (AIS) relative to observation (watchful waiting).

Weinstein SL, Dolan LA, Wright JG, Dobbs MB. Effects of bracing in adolescents with idiopathic scoliosis. N Engl J Med. 2013;369(16):1512-1521. [PMID: 23232372]


Cancer and Blood Disorders

Ben Watkins, MD, Assistant Professor at Emory University, has earned an NIH K23 grant for his work with allogeneic hematopoietic stem cell transplantation (HCT), which is an effective treatment for hematological malignancy. However, significant complications limit its widespread application. Chronic graft-versus-host disease (GVHD) is the leading cause of long-term morbidity and mortality following HCT, and recent advances have failed to reduce the frequency or severity of this devastating complication. The mechanisms of the development and evolution of chronic GVHD have not been clearly defined, thus challenging progress in the design of new therapeutic approaches aimed at preventing or treating the disease. Flow cytometry and gene expression profiling have emerged as valuable tools to interrogate complex disease states and define the molecular changes that occur during the development of disease.

The long-term approach of this work is to identify the mechanistic drivers of chronic GVHD to aid in our understanding of the disease and help elucidate targetable pathways to alter its natural history. To identify the mechanisms driving GVHD, we have developed a systems biology approach that combines longitudinal flow cytometry with gene expression analysis linked to detailed clinical data. Utilizing data from an ongoing multi-center clinical trial investigating GVHD, we will apply supervised and unsupervised approaches to determine the molecular signature of T and B cells linked to the development and evolution of chronic GVHD.