Scientific Publications and Presentations

Publications

Cancer and Blood Disorders

Bakshi, N., Smith, M. E., Ross, D. and Krishnamurti, L. (2017). Novel Metrics in the Longitudinal Evaluation of Pain Data in Sickle Cell Disease. The Clinical Journal of Pain, 33(6), 517-527. doi:10.1097/ajp.0000000000000431

Bakshi, N., Lukombo, I., Shnol, H., Belfer, I. and Krishnamurti, L. (2017). Psychological Characteristics and Pain Frequency Are Associated with Experimental Pain Sensitivity in Pediatric Patients with Sickle Cell Disease. The Journal of Pain. doi:10.1016/j.jpain.2017.05.005

, Fay M., Sakurai Y., McFarland B., Blanche S., Diprete C., Joiner C.H., Sulchek T. and Lam W.A. (2017) Normal Saline is Associated with Increased Sickle Red Cell Stiffness and Prolonged Transit Times in a Microfluidic Model of the Capillary System. Microcirculation. doi: 10.1111/micc.12353. [Epub ahead of print]

Dampier, C., Palermo, T.M., Darbari, D.S., Hassell, K., Smith, W. and Zempsky, W. (2017) AAPT Diagnostic Criteria for Chronic Sickle Cell Disease Pain; Journal of Pain 2017. doi: 10.1016/j.jpain.2016.12.016.

Liu W., Yu W.M., Zhang J., Chan R.J., Loh M.L., Zhang Z., Bunting K.D. and Qu, C.K. (2017) Inhibition of the Gab2/PI3K/mTOR signaling ameliorates the myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations. Leukemia. In press.

Mannino R.G., Santiago-Miranda A.N., Pradhan P., Qiu Y., Mejias J.C., Neelapu S.S., Roy K. and Lam W.A. (2017) 3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro. Lab on a Chip, 17(3), 407-414. doi: 10.1039/c6lc01204c

Myers D.R., Qiu Y., Fay M.E., Tennenbaum M., Chester D., Cuadrado J., Sakurai Y., Baek J., Tran R., Ciciliano J.C., Ahn B., Mannino R.G., Bunting S.T., Bennett C., Briones M., Fernandez-Nieves A., Smith M.L., Brown A.C., Sulchek T. and Lam W.A.(2017) Single-platelet nanomechanics measured by high-throughput cytometry. Nature Materials, 16(2), 230-235. doi: 10.1038/nmat4772. PMID: 27723740

O’Leary H.A.,  Capitano M., Cooper S.,  Mantel C., Boswell H.S., Kapur R., Ramdas B., Chan R., Deng L., Qu C.K., and  H.E. Broxmeyer. (2017) DPP4 Truncated GM-CSF & IL-3 Manifest Distinct Receptor Binding and Regulatory Functions Compared to their Full Length Forms. Leukemia. 2017. In press.

Quarmyne M.O., Dong W., Theodore R., Anand S., Barry V., Adisa O., Buchanan I.D., Bost J., Brown R.C., Joiner C.H. and Lane P.A. (2017) Hydroxyurea effectiveness in children and adolescents with sickle cell anemia: A large retrospective, population-based cohort. American Journal of Hematology, 92(1), 77-81. doi: 10.1002/ajh.24587. Epub Nov. 18, 2016. PMID: 27761932

Siegel D.A., Claridy M., Mertens A., George E., Vangile K., Simoneaux S.F., Meacham L.R. and Wasilewski-Masker K. (2017) Risk factors and surveillance for reduced bone mineral density in pediatric cancer survivors. Pediatric Blood & Cancer. doi: 10.1002/pbc.26488. [Epub ahead of print]

Cardiology

Q1 Publications: January-March 2017

Phelps HM, Kelleman MS, McCracken CE, Benavidez OJ, Campbell RM, Douglas PS, Eidem BW, Lai WW, Lopez L, Stern KW, Welch E, Sachdeva R. Application of Pediatric Appropriate Use for Initial Outpatient Evaluation of Syncope. Echocardiography. 2017 Mar;34(3):441-445. doi: 10.1111/echo.13475. Epub 2017 Feb 8.

Hoeting NM, McCracken CE, McConnell M, Sallee D, Iannucci GJ, Oster ME. Systolic ejection click versus split first heart sound: Are our ears deceiving us? Congenit Heart Dis. 2017 Mar 16 [Epub ahead of print]

Hashemi S, Parks WJ, Sallee D 3rd, Slesnick T. Double Aortic Arch With Previously Undescribed Head and Neck Vessel Branching. Can J Cardiol. 2017 Apr;33(4):555.e21-555.e23.

Tree M, Trusty PM, Slesnick TC, Yoganathan A, Deshpande S, Maher K. In Vitro Examination of the HeartWare CircuLite Ventricular Assist Device in the Fontan Connection. ASAIO J. 2017 Jan 20. doi: 10.1097/MAT.0000000000000521. [Epub ahead of print]

Rose-Felker K, Border WL, Hong BJ, Chow EJ. Cardio-oncology Related to Heart Failure: Pediatric Considerations for Cardiac Dysfunction. Heart Fail Clin. 2017 Apr;13(2):311-325. doi: 10.1016/j.hfc.2016.12.007. Review. PubMed PMID: 28279417.

Grant EK, Kim DW, Border WL, Lerakis S, Babaliaros V, Vincent RN. Transseptal Anchored Vascular Plug Closure of Mitral Valve Perforation. JACC Cardiovasc Interv. 2017 Mar 13;10(5):e45-e46. doi: 10.1016/j.jcin.2016.12.004. Epub 2017 Feb 15. PubMed PMID: 28216218.

McLaughlin ES, Travers C, Border WL, Deshpande S, Sachdeva R. Tricuspid annular plane systolic excursion as a marker of right ventricular dysfunction in pediatric patients with dilated cardiomyopathy. Echocardiography. 2017 Jan;34(1):102-107. doi: 10.1111/echo.13416. Epub 2016 Dec 9. PubMed PMID: 27933640

Alsoufi B, McCracken C, Shashidharan S, Kogon B, Border W, Kanter K. Palliation Outcomes of Neonates Born With Single-Ventricle Anomalies Associated With Aortic Arch Obstruction. Ann Thorac Surg. 2017 Feb;103(2):637-644. doi: 10.1016/j.athoracsur.2016.06.040. Epub 2016 Sep 1. PubMed PMID: 27592600.

Naguib M, Kanaan U, Simon D, Guglani L. Risk factors for development of PH in infants with BPD: systemic review and meta-analysis. Paediatric Respiratory Reviews (epub ahead of print)

Hebson C, Book W, Elder R, Ford R, Jokhadar M, Kanter K, Kogon B, Kovacs AH, Levit RD, Lloyd M, Maher K, Reshamwala P, Rodriguez F, Romero R, TejadaT, Marie, Valente A, Veldtman G, McConnell M.. Frontiers in Fontan failure: A summary of conference proceedings. Congenit Heart Dis 12:6-16, 2017.

Jacobs JP, LaheySJ, Nichols FC, Levett JM, Johnston GG, Cleveland JC, DiSesa VJ, Freeman RK, St. Louis JD, Painter J, Yohe C, Wright CD, Kanter KR, Mayer JE, Naunheim KS, Rich JB, Bavaria JE: How is physician work valued? Ann Thorac Surg 103:373-80, 2017.

Nathan M, Jacobs ML, Gaynor JW, Newburger JW, Masterson CD, Lambert LM, Hollenbeck-Pringle D, Trachtenberg FL, White O, Anderson BR, Bell MC, Burch PT, Graham EM, Kaltman JR, Kanter KR, Mery CM, Pizarro C, Schamberger MS, Taylor MD, Jacobs JP, Pasquali SK: Completeness and accuracy of local clinical registry data for children undergoing heart surgery.  Ann Thorac Surg 103:629-36, 2017.

Baldwin JT, Adachi I, Teal J, Almond CA, Jaquiss RD, Massicotte MP, Dasse K, Siami FS, Zak V, Kaltman JR, Mahle WT, Jarvik R. Closing in on the PumpKIN Trial of the Jarvik 2015 Ventricular Assist Device.  Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2017 Jan;20:9-15.

Karsch E, Irving SY, Aylward BS, Mahle WT. The prevalence and effects of aspiration among neonates at the time of discharge. Cardiol Young. 2017 Feb 6:1-7. doi: 10.1017/S104795111600278X. [Epub ahead of print]

Sacks JH, Flueckiger PB, Spandorfer PR, Mahle WT, Costello BE. Adult Chest Pain in the Pediatric Emergency Department: Treatment and Timeliness From Door In To Door Out. Pediatr Emerg Care. 2017 Mar 21. doi: 10.1097/PEC.0000000000001081 [Epub ahead of print]

Rose-Felker K, Kelleman MS, Campbell RM, Sachdeva R. Appropriateness of Outpatient Echocardiograms Ordered by Pediatric Cardiologists or Other Clinicians. J Pediatr. 2017 Feb 24. pii: S0022-3476(17)30183-X. doi: 10.1016/j.jpeds.2017.01.073. [Epub ahead of print]

Q2 Publications: April-June 2017

Kogon B, Fernandez J, Shashidharan S, Kanter K, Alsoufi B. A 30-year experience with mixed-type total anomalous pulmonary venous connection: a word of caution. Cardiol Young 27: 870-76, 2017

Nathan M, Jacobs ML, Gaynor JW, Newburger JW, Masterson CD, Lambert LM, Hollenbeck-Pringle D, Trachtenberg FL, White O, Anderson BR, Bell MC, Burch PT, Graham EM, Kaltman JR, Kanter KR, Mery CM, Pizarro C, Schamberger MS, Taylor MD, Jacobs JP, Pasquali SK: Completeness and accuracy of local clinical registry data for children undergoing heart surgery.  Ann Thorac Surg 103:629-36, 2017.

Rose-Felker K, Border WL, Hong BJ, Chow EJ. Cardio-oncology related to heart failure: pediatric considerations for cardiac dysfunction. Heart Fail Clin. 2017 Apr;13(2):311-325. 

Nguyen T, Fundora MP, Welch E, Douglas PS, Eidem BW, Campbell RM, Weiner RB, Stern KW, Benavidez OJ, Lai WW, Sachdeva R, Lopez L. Application of the Pediatric Appropriate Use Criteria for Chest Pain. J Pediatr. 2017 Mar 30. pii: S0022-3476(17)30339-6. doi: 10.1016/j.jpeds.2017.02.073. [Epub ahead of print]

Vyas-Read S, Kanaan U, Shankar P, Stremming J, Travers C, Carlton DP, Fitzpatrick A.  Early characteristics of infants with pulmonary hypertension in a referral neonatal intensive care unit. BMC Pediatrics, July 2017, 17:163

Morray BH, Dimas VV, Lim S, Balzer DT, Parekh DR, Van Mieghem NM, Ewert P, Kim DW, Justino H, McElhinney DB, Jones TK, (2017) Circulatory support using the Impella device in Fontan patients with systemic ventricular dysfunction: a multicenter experience, Catheterization and Cardiovascular Interventions

Babaliaros, VC, Greenbaum, AB, Khan. JM, Rogers, T, Wang, D, Eng, MH, O’Neill, W.W., Paone, G, Thourani, VH, Lerakis, S, Kim, DW, Chen, MY, Lederman, RJ, (2017) Intentional Percutaneous Laceration of the Anterior Mitral Leaflet to Prevent Outflow Obstruction During Transcatheter Mitral Valve Replacement, First in Human Experience, JACC Cardiovascular Interventions, 10(8): 798-809

Rostad CA, Wehrheim K, Kirklin JK, Naftel D, Pruitt E, Hoffman TM, L'Ecuyer T, Berkowitz K, Mahle WT, Scheel JN.  Bacterial infections after pediatric heart transplantation: Epidemiology, risk factors and outcomes.  J Heart Lung Transplant. 2017 May 11 pii: S1053-2498(17)31790-4

Oster ME, Watkins S, Hill KD, Knight JH, Meyer RE. Academic Outcomes in Children with Congenital Heart Defects: A Population-based Cohort Study. Circulation: Cardiovascular Quality & Outcomes. (Epub)

Finn KB, Farr Sl, Oster ME. Preparing Adolescents with Heart Disease for Transition to Adult Care in the 2009-2010 National Survey of Children with Special Health Care Needs. Congenit Heart Dis. 2017 May 19. (Epub)

Petit CJ, Glatz AC, Qureshi AM, Sachdeva R, Maskatia SA, Justino H, Goldberg DJ, Mozumdar N, Whiteside W, Rogers LS, Nicholson GT, McCracken C, Kelleman M, Goldstein BH.  Outcomes after decompression of the right ventricle in infants with pulmonary atresia with intact ventricular septum are associated with degree of tricuspid regurgitation, Results from the Congenital Catheterization Research Collaborative.  Circulation: Cardiovascular Interventions, May 2017.

Hebson C, Ephrem G, Rodriguez F. Coincidental Significant Tricuspid Regurgitation at the Time of Right Ventricle-to-Pulmonary Artery Conduit Intervention: Should We Address it, Ignore it, or Take a More Nuanced Approach? JACC Cardiovasc Interv. 2017 Apr 10;10(7):709-711.

Everitt IK, Gerardin JF, Rodriguez FH 3rd, Book WM. Improving the quality of transition and transfer of care in young adults with congenital heart disease. 2017 May 12(3):242-250.

Hashemi S, Parks WJ, Sallee D 3rd, Slesnick T. “Double Aortic Arch With Previously Undescribed Head and Neck Vessel Branching.”  Can J Cardiol. 2017 Apr;33(4):555.e21-555.e23

Fernandes BA, Maher KO, Deshpande SR. Cardiac biomarkers in pediatric heart disease: A state of art review. World J Cardiol. 2016 Dec 26;8(12):719-727. doi: 10.4330/wjc.v8.i12.719. Review. PMID: 28070239 [PubMed]

Deshpande SR, Dalal A, Kim DW, Babaliaros V, Jokhadar M. Acute emoblic myocardial infarction and heart failure in a Fontan patient: recovery with impella device and successful transplantation. ASAIO J. 2016 Nov/Dec;62(6):e52-e54. PMID: 27045968 [PubMed - in process]

Botha P, Deshpande SR, Wolf M, Heard M, Alsoufi B, Kogon B, Kanter K. Extracorporeal membrane oxygenator support in infants with systemic-pulmonary shunts. J Thorac Cardiovasc Surg. 2016 Sep;152(3):912-8. doi: 10.1016/j.jtcvs.2016.03.075. Epub 2016 Apr 11. PMID: 27530641 [PubMed - in process]

Hastings SM, Deshpande SR, Wagoner S, Maher K, Ku DN. Thrombosis in centrifugal pumps: location and composition in clinical and in vitro circuits. Int J Artif Organs. 2016 Jun 15;39(4):200-4. doi: 10.5301/ijao.5000498. Epub 2016 Jun 2. PMID: 27323916 [PubMed - indexed for MEDLINE]

Deshpande SR, Shehata BM, Sallee D, Kogon BE, Mahle WT. Late primary transplantation in complex congenital heart disease. Pediatr Transplant. 2016 Mar;20(2):325-8. doi: 10.1111/petr.12676. Epub 2016 Jan 25. PMID: 26803993 [PubMed - indexed for MEDLINE]

Deshpande SR, Herman HK, Quigley PC, Shinnick JK, Cundiff CA, Caltharp S, Shehata BM. Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D): review of 16 pediatric cases and a proposal of Modified Pediatric Criteria. Pediatr Cardiol. 2016 Apr;37(4):646-55. doi: 10.1007/s00246-015-1327-x. Epub 2016 Jan 8. PMID: 26743400 [PubMed - indexed for MEDLINE]

Butts RJ, Boyle GJ, Deshpande SR, Gambetta K, Knecht KR, Prada-Ruiz CA, Richmond ME, West SC, Lal AK. Characteristics of clinically diagnosed pediatric myocarditis in a contemporary multi-center cohort. Pediatr Cardiol. 2017 Aug;38(6):1175-1182. doi: 10.1007/s00246-017-1638-1. Epub 2017 May 23. PMID: 28536746 [PubMed - in process]

Tree M, Trusty PM, Slesnick TC, Yoganathan A, Deshpande S, Maher K. In vitro examination of the Heartware CircuLite Ventricular Assist Device in the Fontan connection. ASAIO J. 2017 Jul/Aug;63(4):482-489. doi: 10.1097/MAT.0000000000000521. PMID: 28118264 [PubMed - in process]

Deshpande SR, Kasniya G, Cuadrado AR, Maher KO. Idiopathic infantile arterial calcification: a case report of successful extracorporeal membrane oxygenation support. Int J Artif Organs. 2017 Jan 13;39(11):575-579. doi: 10.5301/ijao.5000544. Epub 2017 Jan 12. PMID: 28085170 [PubMed - as supplied by publisher]

McLaughlin ES, Travers C, Border WL, Deshpande S, Sachdeva R. Tricuspid annular plane systolic excursion as a marker of right ventricular dysfunction in pediatric patients with dilated cardiomyopathy. Echocardiography. 2017 Jan;34(1):102-107. doi: 10.1111/echo.13416. Epub 2016 Dec 9. PMID: 27933640 [PubMed - indexed for MEDLINE]

Hastings SM, Ku DN, Wagoner S, Maher KO, Deshpande S. Sources of circuit thrombosis in pediatric extracorporeal membrane oxygenation. ASAIO J. 2017 Jan/Feb;63(1):86-92. doi: 10.1097/MAT.0000000000000444. PMID: 27660905 [PubMed - in process]

Alsoufi B, Gillespie S, Mahle WT, Deshpande S, Kogon B, Maher K, Kanter K. The effect of noncardiac and genetic abnormalities on outcomes following neonatal congenital heart surgery. Semin Thorac Cardiovasc Surg. 2016 Spring;28(1):105-14. doi: 10.1053/j.semtcvs.2015.10.016. Epub 2015 Nov 17. PMID: 27568146 [PubMed - indexed for MEDLINE]

Concussion

Keith H. May, P.T., D.P.T., S.C.S., A.T.C., C.S.C.S., David L. Marshall, M.D., Thomas G. Burns, Psy.D., ABPP/CN, David M. Popoli, M.D., John A. Polikandriotis, Ph.D., MBA, MPH, FACHE. Pediatric sports specific return to play guidelines following concussion. International Journal of Sports Physical Therapy, 9(2), pp. 242-255.

David Popoli, M.D., Thomas G. Burns, Psy.D., ABPP/CN, Meehan WP 3rd, Andrew Reisner, M.D. CHOA concussion consensus: establishing a uniform policy for academic accommodations. Clinical Pediatrics. 2014 Mar;53(3):217-24. doi: 10.1177/0009922813499070. Epub 2013 Aug 19.
Read more

Andrew Reisner, M.D., F.A.C.S., F.A.A.P.; Natalie Tillman, R.N., B.S.N.; Linda Cole, R.N.; Elizabeth Atkins, R.N.; Greg Pereira, R.N., B.S.N., M.B.A., Mary Thacher, R.N., MSN, CEN. Concussion in Children. Neuro Update Vol 5, Issue 1, 2011. Dr. Reisner and the Children’s concussion team take a look at the history of concussions and provide insight into the definitions, guidelines and treatments for a condition that affects millions of children each year.

Burns, T.G. & Yosick, R. (2012). Book Review: Kirkwood, M.W., & Yeates, K.O. (2012). Mild Traumatic Brain Injury in Children and Adolescents: From Basic Science to Clinical Management. New York, NY. The Guilford Press. Applied Neuropsychology: Child, 2(1), pp.78-79.

Arenivas, A. & Burns, T.G. (2012). Recent Trends in Pediatric and Adolescent Concussion: How to Diagnose and Treat This Condition. Book Review: Apps, J.N. & Walter, K.D. (Eds). (2012). Pediatric and Adolescent Concussion: Diagnosis, Management, and Outcomes. New York: Springer. The Clinical Neuropsychologist, 1-3.

American Academy of Pediatrics. Point of Care Quick Reference: Head Injuries. Pediatric Care Online.

Atabaki SM. Pediatric head injury. Pediatrics in Review. 2007 Jun; 28(6): 215-24.
Bin, SS, Schutzman SA and Greenes DS. Validation of a clinical score to predict skull fracture in head injured infants. Ped Emer Care 26 (9) Sept 2010: 633-639.

Brody AS, Frush DP and Brent RL. Radiation risk to children from computed tomography. PED 120(3) Sept 2007; 677-682.

Centers for Disease Control and Prevention. Heads up: concussion in youth sports.

Hall Eric J. Lessons we have learned from our children: cancer risks from diagnostic radiology.
Pediatr Rad (2002)32:700-706.

Kluger J. (2011, January 31). Headbanger nation. Time, 177, 42-51.

Kupperman N et al. Identification of children at very low risk of clinically important brain injuries after head trauma: a prospective cohort. Lancet 2009: 374:1160-70.

Palchak MJ et al. A decision rule for identifying children at low risk for brain injuries after blunt head trauma. Ann Emer Med Oct 2003: 42:4; 492-506.

Palchak MJ et al. Does an isolated history of low of consciousness or amnesia predict brain injuries in children after blunt head trauma? PED 113:6; June 2004; e507-513.

Pauline Anderson. (2010, September 10). New guidance on management of increasing problem of sports-related concussions in children. Medscape Medical News.

Practice guidelines: the management of minor closed head injury in children. PED 1998; 104; 6:1407-1415.

Schnadower D et al. Controversies in the evaluation and management of minor blunt head trauma in children. Curr Opin Ped 2007;19:258-264.

Schutzman SA et al. Evaluation and management of children younger than two years old with apparently minor head trauma: proposed guidelines. PED 107(5) May 2001 983-993.

Neurology

Language and social functioning in children and adolescents with epilepsy. Byars AW, DeGrauw TJ, Johnson CS, Perkins SM, Fastenau PS, Dunn DW, Austin JK. Epilepsy Behav. 2014 Feb;31:167-71. doi: 10.1016/j.yebeh.2013.11.007. Epub 2014 Jan 14

Neuropsychology

Howarth, R.A., Reisner, A., Chern, J., Hayes, L., Burns, T.G., & Berenstein, A. (2015). Neurocognitive improvements following endovascular repair for Vein of Galen arteriovenous malformation in childhood: A case report. Journal of Neurosurgery: Pediatrics, 15, 197-202.

Burns, T.G. & Loring, D.W (2015). Psychological and social impact of epilepsy: pediatric and adolescent review. Journal of Pediatric Epilepsy, 4(3), pp. 1-7.

Reisner, A., Popoli, D.M., Burns, T.G., Marshall, D.L., Jain, S., Hall, L., Vova, J.A., Kroll, S., Wesselman, B.C., Palasis, S., Hayes, L., Clark, G., Speake, K.M., Holbrook, B.H., Wiskind, R.H., Licata, R.M., Ono, K.E., Hogan, E., Chern, J., DeGrauw, T. (2015). The Central Role of Community Practicing Pediatricians in Contemporary Concussion Care: A Case Study of CHOA’s Concussion Program. Clinical Pediatrics, pp. 1-7

Bodin, D., Roper, B., O’Toole, K., & Haines, M.E. (2015). Postdoctoral training in clinical neuropsychology: A review of the history, trends, and current issues. Training and Education in Professional Psychology.

McManus, S. & O’Toole, K. (2014). Book Review: Language Disorders in Children and Adolescents, by Joseph H. Beitchman & Elizabeth B. Brownlie. Child Neuropsychology. Published online: 23 May, 1-3.

Howarth, R.A., Adamson, A.M., Ashford, J.M., Merchant, T.E., Ogg, R.J., Schulenberg, S.E., Ogg, S., Li, J., Wu, S., Xiong, X, & Conklin, H.M. (2014). Investigating the relationship between COMT polymorphisms and working memory performance among childhood brain tumor survivors. Pediatric Blood & Cancer, 61, 40-45.

Jackson, S., Patay, Z., Howarth, R.A., Panandiker, A.S., Onar-Thomas, A., Gajjar, A., & Broniscer, A. (2013). Clinico-radiologic characteristics and neurocognitive assessment of long-term survivors of diffuse intrinsic pontine glioma. Journal of Neuro-Oncology, 114, 339-344.

Howarth, R.A., Ashford, J.M., Merchant, T.E., Ogg, R.J., Santana, V., Wu, S., Xiong, X., & Conklin, H.M. (2013). The utility of parent report in the assessment of working memory among childhood brain tumor survivors. Journal of the International Neuropsychological Society, 19, 380-389.

Alriksson-Schmidt, A.I., Thibadeau, J.K., Swanson, M.E., Marcus, D., Carris, K.L., Siffel, C., Ward, E., (2013). The Natural History of Spina Bifida in Children Pilot Project: A Research Protocol. JMIR Research Protocols (2013)

Sun, B., Berl, M.M., Burns, T.G., Gaillard, W.D., Hayes, L., Adjouadi, M., & Jones, R.A (2013). Age Association of Language Task Induced Deactivation Induced in a Pediatric Population. Neuroimage, 65, 232-33.

Burns, T.G., King, T.Z., & Spencer, K.S. (2012). Mullen Scales of Early Learning: The Utility in Assessing Children with Autism Spectrum Disorders, Cerebral Palsy, and Epilepsy. Journal of Applied Neuropsychology: Child, 1, pp. 1-10.

Sun, B., Brown, R.C., Hayes, L., Burns, T.G., Huamani, J., Bearden, D.J., & Jones, R.A. (2012). White matter damage in asymptomatic patients with sickle cell anemia: Screening with diffusion tensor imaging. American Journal of Neuroradiology, 33, pp. 1-7.

Burns, T.G. (2012). Book Review: Sherman, E.M.S., & Brooks, B.L. (Eds). (2012). Pediatric forensic Neuropsychology. New York, NY: Oxford University Press. Applied Neuropsychology: Child, (In press)

Christopher, G. & O’Toole, K. (2012). Book Review: Barkley, Russell. Executive Functions. New York: Guilford Press. “The chasm cries out for a bridge.” Child Neuropsychology, iFirst, 1-4.

Micklewright, J.L., King, T.Z., O’Toole, K., Henrich, C., & Floyd, F.J. (2012). Authoritarian Parenting Partially Mediates the Relationship between Parental Stress and Child Adaptive Outcomes 12-36 Months Following Traumatic Brain Injury. Journal of the International Neuropsychological Society, 18, 1-8.

Conklin, H.C., Ashford, J.A., Howarth, R.A., Merchant, T.E., Ogg, R.J., Santana, V., et al. (2012). Working memory performance among childhood brain tumor survivors. Journal of the International Neuropsychological Society, 18, 996-1005.

Neurosurgery

Read selected journal articles authored/co-authored by our surgeons available at PubMed, the online database provided by the U.S. National Library of Medicine National Institutes of Health publications:

View more on PubMed

Return to system within 30 days of discharge following pediatric shunt surgery. Joshua J. Chern, M.D., Ph.D., Markus Bookland, M.D., Javier Tejedor-Sojo, M.D., Jonathan Riley, M.D., Mohamm adali M. Shoja, M.D., R. Shane Tubb s, Ph.D., P.A.-C., and Andrew Reisner, M.D. J Neurosurg: Pediatrics / March 14, 2014 DOI: 10.3171/2014.2.PEDS13493

Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres. Anjana Jain, Martha Betancur, Gaurangkumar D. Patel, Chandra M. Valmikinathan, Vivek J. Mukhatyar, Ajit Vakharia, S. Balakrishna Pai, Barunashish
Brahma, Tobey J. MacDonald & Ravi V. Bellamkonda. Nature Materials 13, 308–316 (2014) doi:10.1038/nmat3878. Published online 16 February 2014

Aguilera, Flamini, Boydston, et al; Response of subependymal giant cell astrocytoma with spinal cord mestasis to everolimus. Journal of Pediatric Hematology/Oncology

Reisner A, Gary MF, Chern JJ, D Grattan-Smith: Spinal cord infarction following minor trauma in children; Fibrocartilaginous embolism as a putative cause: J Neurosurgery: Pediatrics, April Vol 11, 445-450, 2013.

Kebriaei MA, Shoa MM, Salinas SM, Falkenstrom KL, Sibnick, EA, Tubbs RS, Reisner A,Chern JJ; Shunt infection in the first year of life. Journal of Neurosurgery: Pediatrics July 12:44-48, 2013.

David M. Popoli, MD, Thomas Burns, PhD, William Meehan III, MD, Andrew Reisner, MD. CHOA Concussion Consensus: Establishing a Uniform Policy for Academic Accomodations. J Pediatrics (accepted)

A Heads up on Craniosynostosis, Andrew Reisner, M.D., William R. Boydston, M.D., Ph.D., Barun Brahma, M.D.; Joshua Chern, M.D., Ph.D., David Wrubel, M.D.

Abnormalities of Headshape in an Infant, Andrew Reisner, M.D., William R. Boydston, M.D., Ph.D., Barun Brahma, M.D.; Joshua Chern, M.D., Ph.D., David Wrubel, M.D.

Neuro Spine Care for Kids, David Wrubel, M.D., and Barun Brahma, M.D.

The "Epidemic" of Occipital Flattening: Why It Is Happening and What To Do About It, Andrew Reisner, M.D., William R. Boydston, M.D., Ph.D., Barun Brahma, M.D.; Joshua Chern, M.D., Ph.D., David Wrubel, M.D.

Pediatric Radiosurgery and Gamma Knife, Andrew Reisner, M.D., F.A.C.S., F.A.A.P.

Low Grade Leptomeningeal Neuroepithelial Tumor, Schniederjan, et al

Evans Blue Nanocarriers Visuall Demarcate Margins of Invasive Gliomas, Roller, et al

Nanofiber Transport of Brain Tumors, Jain et al

The Use of Inside-Outside Screws for Occipitocervial Fusion in Pediatric Patients – Accepted for publication in the Journal of Neurosurgery: Pediatrics

Transient enlargement of craniopharyngioma after radiation therapy; Pattern of MRI response following radiation. Journal of Neurooncology September 2012; 109(2); 349-55

Maurice SM, Brahma B, Burnstein FD. Disappearing dermoid: Fact or Fiction? Journal of Craniofacial Surgery. May 2012; 23(3): 812-6

Nanoparticle Liposome-Imipramine Blue inhibits medulloblastoma in SmoA1 transgenic mice.

Chern JJ, Kirkman JL, Shannon CN, Tubbs RS, Stone JD, Royal SA, Oakes WJ, Rozzelle CJ, Wellons JC. Use of lumbar ultrasonography to detect occult spinal dysraphism. Journal Neurosurgery Pediatric. 9(3):274-9, 2012.

Tubbs RS, Hattab EM, Loukas M, Chern JJ, Wellons M, Wellons JC 3rd, Iskandar BJ, Cohen-Gadol AA. Histological analysis of the third ventricle floor in hydrocephalic and non hydrocephalic brains: application to neuroendocrine complications following third ventriculostomy procedures. Journal Neurosurgery Pediatrics. 9(2):178-181, 2012.

Chern JJ, Tubbs RS, Gordon AS, Donnithorne KJ, Oakes WJ. Management of Pediatric Patients with Pseudotumor Cerebri. Childs Nerv Syst. 28(4):575-578, 2012 Jan 19.

Chern JJ, Muhleman M, Tubbs RS, Miller JH, Johnston JM, Wellons JC 3rd, Blount JP, Oakes WJ, Rozzelle CJ. Clinical evaluation and surveillance imaging in children with Spina Bifida aperta and shunt-treated hydrocephalus. J Neurosurgery Pediatrics. 9(6): 621-6, 2012.

Hwang SW, Gressot LV, Chern JJ, Relyea K, Jea A. Complications of Occipital Screw Placement for Occipitolcervical Fusion in Childres. J Neurosurgery Pediatrics. 9(6); 586-93, 2012.

Tubbs RS, Chern JJ, Muhleman M, Loukas M, Shoja MM, Oakes WJ. Lateral Compressions of the Foramen Magnum with the Chiari 1 Malformation: case illustrations. Childs Nerv Syst Apr 19, 2012.

Tubbs RS, Muhleman M, McClugage SG, Loukas M, Miller JH, Chern JJ, Rozzelle CJ, Oakes WJ, Cohen-Gadol AA. Progressive symptomative increase in the size of choroidal fissure cysts. J Neurosurg Pediatr 10(4):306-9, 2012.

Chern JJ, Aksut B, Kirkman JL, Shoja MM, Tubbs RS, Royal SA, Wellons JC 3rd, Rozzelle CJ. The accuracy of abnormal lumbar sonography findings in detecting occult spinal dysraphism: a comparison with magnetic resonance imaging. J Neurosurg Pediatr. 10(2): 150-3, 2012.

Kebriaei MA, Shoa MM, Salinas SM, Falkenstrom KL, Sibnick, EA, Tubbs RS, Reisner a. Chern JJ; Shunt infection in the first year of life. Journal of Neurosurgery: Pediatrics July 12:44-48, 2013.

Chern JJ. Response, Spinal dysraphism. J Neurosurg Pediatr. 11(5): 613, 2013.

Tubbs RS, Mortazavi MM, Farrington WJ, Chern JJ, Shoja MM, Loukas M, Cohen-Gadol AA. Relationships between the posterior interosseous nerve and the supinator muscle: application to peripheral nerve compression syndromes and nerve transfer procedures. J Neurol Surg A Cent Eur Neurosurg, 2013 May 21.

Reisner A, Gary MF, Chern JJ, D Grattan-Smith: Spinal cord infarction following minor trauma in children; Fibrocartilaginous embolism as a putative cause: J Neurosurgery: Pediatrics, April Vol 11, 445-450, 2013.

Rizk E, Chern JJ, tagayun C, Tubbs RS, Hankinson T, Rozzelle CJ, Oakes WJ, Blount JP, Wellons JC. Institutional experience of endoscopic suprasellar arachnoid cyst fenestration. Childs Nerv Syst Jan 24, 2013.

Shoja MM, Chern JJ. Letter to the editor: Decompressive craniectomy. J Neurosurg Pediatr 11(3): 358, 2013.

Orthopaedics

Micheli anterior cruciate ligament reconstruction in skeletally immature youths: A retrospective case series with a mean 3-year follow up

PI: S. Clifton Willimon, M.D., Michael Busch M.D.
This study is to evaluate the clinical outcomes of a physeal-sparing technique using the illotibial band for combined intra-articular and extra-articular ACL reconstruction. At a mean 3-year follow-up, the study findings confirmed excellent functional outcomes, a low ACL revision rate, and no growth disturbances.

Willimon SC, Jones CR, Herzog MM, May KH, Leake MJ, Busch MT. Micheli anterior cruciate ligament reconstruction in skeletally immature youths: A retrospective case series with a mean 3-year follow-up. Am J Sports Med. 2015 [Epub ahead of print] PMID: 26498959

Subscapularis avulsion of the lesser tuberosity in adolescent

PI: Michael Busch M.D.
This study is a long-term clinical follow-up study of patients with isolated lesser tuberosity avulsions in skeletally immature patients. Operative treatment consisted of a diagnostic arthroscopy to evaluate for concomitant pathology, followed by an open reattachment of the tuberosity through an incision in line with the anterior axillary fold.

Garrigues GE, Warnick DE, Busch MT. Subscapularis avulsion of the lesser tuberosity in adolescent. J Pediatr Orthop. 2013;33(1):8-13. [PMID 23232372]

Effects of bracing in adolescents with idiopathic scoliosis (BrAIST)

PI: Michael Schmitz, M.D., National Institutes of Health
The BrAIST study is a Phase III, multicenter, prospective partially-randomized, partially blinded clinical trial, designed to determine whether the use of the thoracolumbosacral orthoses (brace) lowers the risk of curve progression in patients with adolescent idiopathic scoliosis (AIS) relative to observation (watchful waiting).

Weinstein SL, Dolan LA, Wright JG, Dobbs MB. Effects of bracing in adolescents with idiopathic scoliosis. N Engl J Med. 2013;369(16):1512-1521. [PMID: 23232372]

Grants

Cancer and Blood Disorders

Ben Watkins, MD, Assistant Professor at Emory University, has earned an NIH K23 grant for his work with allogeneic hematopoietic stem cell transplantation (HCT), which is an effective treatment for hematological malignancy. However, significant complications limit its widespread application. Chronic graft-versus-host disease (GVHD) is the leading cause of long-term morbidity and mortality following HCT, and recent advances have failed to reduce the frequency or severity of this devastating complication. The mechanisms of the development and evolution of chronic GVHD have not been clearly defined, thus challenging progress in the design of new therapeutic approaches aimed at preventing or treating the disease. Flow cytometry and gene expression profiling have emerged as valuable tools to interrogate complex disease states and define the molecular changes that occur during the development of disease.

The long-term approach of this work is to identify the mechanistic drivers of chronic GVHD to aid in our understanding of the disease and help elucidate targetable pathways to alter its natural history. To identify the mechanisms driving GVHD, we have developed a systems biology approach that combines longitudinal flow cytometry with gene expression analysis linked to detailed clinical data. Utilizing data from an ongoing multi-center clinical trial investigating GVHD, we will apply supervised and unsupervised approaches to determine the molecular signature of T and B cells linked to the development and evolution of chronic GVHD.