Overview of Chromosome Abnormalities

What is a chromosome?

The human body is made up of cells. For example, when you have a sunburn, your skin peels, shedding skin cells. At the center of each cell, there is an area called the nucleus.

Human chromosomes are located in the nucleus of the cell. A chromosome is a structure in the nucleus containing your genes. Your genes Anatomy of a celldetermine your traits, such as eye color and blood type.

How are chromosomes inherited?

The usual number of chromosomes in each cell of your body is 46 chromosomes, or 23 pairs. You inherit half of your chromosomes (one member of each pair) from your biological mother, and the other half (the matching member of each pair) from your biological father.

Scientists have numbered the chromosome pairs from one to 22. The 23rd pair is labeled as X's or Y's, depending on the structure. The first 22 pairs of chromosomes are called autosomes. The 23rd pair of chromosomes are known as the sex chromosomes, determining whether someone will be born male or female.

Females have two X chromosomes, and males have one X and one Y chromosome. A picture of all 46 chromosomes, in their pairs, is called a karyotype. A normal female karyotype is written 46, XX, and a normal male karyotype is written 46, XY.